Mesenchymal stem/stromal cells (MSCs) have various properties that make them promising candidates for stem cell-based therapies in clinical settings. These include self-renewal, multilineage differentiation, and immunoregulation. However, recent studies have confirmed that aging is a vital factor that limits their function and therapeutic properties as standardized clinical products. Understanding the features of senescence and exploration of cell rejuvenation methods are necessary to develop effective strategies that can overcome the shortage and instability of MSCs. This review will summarize the current knowledge on characteristics and functional changes of aged MSCs. Additionally, it will highlight cell rejuvenation strategies such as molecular regulation, non-coding RNA modifications, and microenvironment controls that may enhance the therapeutic potential of MSCs in clinical settings.

中文翻译：

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衰老的间充质干/基质细胞及其细胞功能恢复。

间充质干/基质细胞（MSC）具有多种特性，使其成为临床环境中基于干细胞疗法的有希望的候选者。这些包括自我更新，多系分化和免疫调节。但是，最近的研究证实，衰老是限制其作为标准化临床产品的功能和治疗特性的重要因素。了解衰老的特征和探索细胞再生方法对于开发能够克服MSC短缺和不稳定的有效策略是必要的。这篇综述将总结有关衰老的MSC的特征和功能变化的最新知识。此外，它将重点介绍细胞再生策略，例如分子调控，非编码RNA修饰，