Many medications can impact thyroid function. Antiseizure medications have been shown to disrupt thyroid function in adults, but information is limited about how antiseizure medications may affect thyroid function in children. Oxcarbazepine is an analog of carbamazepine designed to minimize effects from the hepatic P450 metabolic enzymes. We have found that in the pediatric population, serum free thyroxine is reduced and thyroid-stimulating hormone concentrations are unchanged in patients taking oxcarbazepine with the mechanism thus being central hypothyroidism.

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奥卡西平治疗中枢性甲状腺功能减退症患者的病例系列

许多药物会影响甲状腺功能。抗癫痫药物已被证明会破坏成人的甲状腺功能，但关于抗癫痫药物如何影响儿童甲状腺功能的信息有限。奥卡西平是卡马西平的类似物，旨在最大限度地减少肝脏 P450 代谢酶的影响。我们发现在儿科人群中，服用奥卡西平的患者血清游离甲状腺素降低，促甲状腺激素浓度不变，其机制是中枢性甲状腺功能减退症。