Cellular senescence plays a very important role in organismal aging increasing with age and in age-related diseases (ARDs). This process involves physiological, structural, biochemical, and molecular changes of cells, leading to a characteristic trait referred to “senescence-associated secretory phenotype (SASP).” In particular, with aging, stem cells (SCs) in situ exhibit a diminished capacity of self-renewal and show a decline in their functionality. The identification of interventions able to prevent the accumulation of senescent SCs in the organism or to pretreat cultured multipotent mesenchymal stromal cells (MSCs) prior to employing them for cell therapy is a main purpose of medical research. Many approaches have been investigated and resulted effective to prevent or counteract SC senescence in humans, as well as other animal models. In this work, we have reviewed the chance of using a number of herb-derived products as novel tools in the treatment of cell senescence, highlighting the efficacy of these agents, often still far from being clearly understood.

中文翻译：

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草药衍生产品：延迟和抵消干细胞衰老的天然工具

细胞衰老在随着年龄增长的机体衰老和与年龄有关的疾病（ARDs）中起着非常重要的作用。此过程涉及细胞的生理，结构，生化和分子变化，从而导致一种称为“衰老相关分泌表型（SASP）”的特征。特别是随着年龄的增长，原位干细胞（SCs）表现出自我更新的能力下降，并且功能下降。在能够将衰老的SCs积聚在生物体中或在将其用于细胞治疗之前对培养的多能间充质基质细胞（MSCs）进行预处理之前，能够识别干预措施是医学研究的主要目的。已经对许多方法进行了研究，结果表明它们可有效预防或抵消人类以及其他动物模型中的SC衰老。在这项工作中，我们综述了将许多草药来源的产品用作治疗细胞衰老的新工具的机会，强调了这些药物的功效，但这些功效通常仍不清楚。