Severe acute respiratory syndrome virus 2 (SARS-CoV-2) induced central nervous system disease has now been recognized as a complication of coronavirus disease (COVID-19) in addition to its multisystem organ infection. How does the central nervous system (CNS) get involved? The possible routes by which SARS-CoV-2 enters the CNS is now an active niche of research worldwide. We had previously hinted the pathway via the nose to the brain across the olfactory mucosa and cribriform plate. Here we detail three pathways by which the infection can ascend to the brain and have highlighted routes that can lead to CNS involvement from other body cavities like the mouth and pharynx. The spaces contained within the ensheathed olfactory nerves connected to the cerebrospinal fluid of the cranial cavity, in particular, has been described in addition to other routes of ascending infection toward the CNS. We implore others to investigate these covert yet important passages to understand the pathogenesis of Neuro-COVID in our fight against SARS-CoV-2 that has changed the lives of the human race in the ongoing pandemic.

中文翻译：

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通往颅腔的秘密途径：这些可能是SARS-CoV-2到达大脑的潜在途径吗？

严重急性呼吸系统综合症病毒2（SARS-CoV-2）引起的中枢神经系统疾病除多系统器官感染外，现已被认为是冠状病毒病（COVID-19）的并发症。中枢神经系统（CNS）如何参与其中？SARS-CoV-2进入CNS的可能途径现在是全世界活跃的研究领域。之前我们曾暗示过鼻腔穿过嗅粘膜和筛状板的途径。在这里，我们详细介绍了三种途径，感染可以通过这种途径上升到大脑，并且突出显示了可能导致其他口腔（如嘴和咽）中枢神经系统受累的途径。包含在嗅觉神经内的空间连接到颅腔的脑脊髓液，特别是 除了对CNS的其他上升感染途径之外，已经描述了其他方法。我们恳请其他人调查这些隐蔽但重要的段落，以了解我们抗SARS-CoV-2的斗争中Neuro-COVID的发病机理，这种变化改变了人类在当前大流行中的生活。