Abstract

Purpose

The aim of the study is to assess association of the duration of diabetes and vibration, proprioception, muscle strength, reaction time and balance measures in people with type 2 diabetes mellitus (DM) without peripheral neuropathy.

Methods

Forty-seven type 2 diabetics without peripheral neuropathy and 23 healthy controls were recruited for the study. Patients with type 2 DM were further classified into 23 patients who suffered from diabetes for less than 5 years (<5yrDM) and 24 patients who had diabetes for 5 years and above (≥5yrDM). All participants were assessed for Michigan neuropathy screening instrument (MNSI), vibration perception threshold (VPT), proprioception, muscles strength, centre of pressure (COP) range, COP sway and reaction time.

Results

≥5yrDM patients were found to significantly differ from healthy control in MNSI score (p ≤ 0.013), VPT score (p ≤ 0.002), reaction time (p ≤ 0.018), COP range (p ≤ 0.005) and COP sway (p ≤ 0.027). A significant difference was found only in reaction time (p < 0.002) except in the back direction (p = 0.089), and COP range (p ≤ 0.016) except in the front (p = 0.101) and right direction (p = 0.085) between <5yrDM patients and healthy controls.

Conclusions

≥5yrDM patients exhibit a subtle deterioration in VPT, reaction time, and balance measure while <5yr DM patients were impaired only in COP range and reaction time when compared with healthy control.

中文翻译：

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2型糖尿病病程与感觉运动功能的关联：超越糖尿病周围神经病变

摘要

目的

该研究的目的是评估糖尿病病程与没有周围神经病变的 2 型糖尿病 (DM) 患者的振动、本体感觉、肌肉力量、反应时间和平衡测量之间的关联。

方法

研究招募了 47 名没有周围神经病变的 2 型糖尿病患者和 23 名健康对照者。2型糖尿病患者进一步分为23例糖尿病小于5年（<5yrDM）和24例糖尿病5年及以上（≥5yrDM）。所有参与者都接受了密歇根神经病变筛查仪 (MNSI)、振动感知阈值 (VPT)、本体感觉、肌肉力量、压力中心 (COP) 范围、COP 摇摆和反应时间的评估。

结果

≥5yrDM患者被发现从在MNSI得分（健康对照显著不同p  ≤0.013），VPT得分（p  ≤0.002），反应时间（p  ≤0.018），COP范围（p  ≤0.005）和COP摇摆（p  ≤0.027 ）。仅在反应时间（p  < 0.002）上发现显着差异（p < 0.002），除了后向（p  = 0.089），COP 范围（p  ≤ 0.016）除了前向（p  = 0.101）和右向（p  = 0.085） <5yrDM 患者和健康对照之间。

结论

与健康对照相比，≥5yrDM 患者在 VPT、反应时间和平衡测量方面表现出微妙的恶化，而 <5yr DM 患者仅在 COP 范围和反应时间方面受损。