Journal of Asian Natural Products Research ( IF 1.7 ) Pub Date : 2020-10-08 , DOI: 10.1080/10286020.2020.1825390 Hoang Le Tuan Anh 1, 2 , Vinh Le Ba 3, 4 , Thi Thao Do 2, 5 , Van Kiem Phan 3 , Hai Yen Pham Thi 2 , Long Giang Bach 6 , Manh Hung Tran 7 , Phuong Anh Tran Thi 2 , Young Ho Kim 4
Abstract
A new compound, physalucoside A (1), together with seven withanolides (2–8) and three flavonoids (9–11), were isolated from Physalis angulata L. (Solanaceae), a medicinal plant native to Vietnam. The chemical structures of these compounds were elucidated by one- and two-dimensional NMR spectra, high-resolution electrospray ionization mass spectrometry analyses, and chemical reactivity. The anti-inflammatory and cytotoxic activities of isolated compounds were also evaluated. These data suggest that the anti-inflammatory activity of P. angulata is due primarily to its withanolide content. This study demonstrates the potential of withanolides as promising candidates for the development of new anti-inflammatory drugs.
中文翻译:
来自酸浆的生物活性化合物及其抗炎和细胞毒活性
摘要
从原产于越南的药用植物Physalis angulata L.(茄科)中分离出一种新化合物,即酸酸钙苷 A ( 1 ),以及 7 种 withanolides ( 2 – 8 ) 和三种黄酮类化合物 ( 9 – 11 ) 。这些化合物的化学结构通过一维和二维核磁共振谱、高分辨率电喷雾电离质谱分析和化学反应性进行了阐明。还评估了分离化合物的抗炎和细胞毒性活性。这些数据表明P. angulata的抗炎活性主要是由于其 withanolide 含量。这项研究证明了山梨醇内酯作为开发新型抗炎药的有希望的候选物的潜力。