The accumulation of biological and biomedical literature outpaces the ability of most researchers and clinicians to stay abreast of their own immediate fields, let alone a broader range of topics. Although available search tools support identification of relevant literature, finding relevant and key publications is not always straightforward. For example, important publications might be missed in searches with an official gene name due to gene synonyms. Moreover, ambiguity of gene names can result in retrieval of a large number of irrelevant publications. To address these issues and help researchers and physicians quickly identify relevant publications, we developed BioLitMine, an advanced literature mining tool that takes advantage of the medical subject heading (MeSH) index and gene-to-publication annotations already available for PubMed literature. Using BioLitMine, a user can identify what MeSH terms are represented in the set of publications associated with a given gene of the interest, or start with a term and identify relevant publications. Users can also use the tool to find co-cited genes and a build a literature co-citation network. In addition, BioLitMine can help users build a gene list relevant to a MeSH term, such as a list of genes relevant to "stem cells" or "breast neoplasms." Users can also start with a gene or pathway of interest and identify authors associated with that gene or pathway, a feature that makes it easier to identify experts who might serve as collaborators or reviewers. Altogether, BioLitMine extends the value of PubMed-indexed literature and its existing expert curation by providing a robust and gene-centric approach to retrieval of relevant information.

生物学和生物医学文献的积累超过了大多数研究人员和临床医生与时俱进的能力，更不用说广泛的话题了。尽管可用的搜索工具支持对相关文献的识别，但是查找相关和重要出版物并不总是那么简单。例如，由于基因同义词，在使用正式基因名称进行搜索时可能会错过重要的出版物。此外，基因名称的歧义会导致检索大量不相关的出版物。为了解决这些问题并帮助研究人员和医师快速识别相关出版物，我们开发了BioLitMine，一种先进的文献挖掘工具，该工具利用了PubMed文献已经提供的医学主题词（MeSH）索引和基因到出版物注释。使用BioLitMine，用户可以识别与目标基因相关的出版物集中代表的MeSH术语，或者以术语开头并识别相关出版物。用户还可以使用该工具查找被引基因并建立文献被引网络。此外，BioLitMine可以帮助用户建立与MeSH术语相关的基因列表，例如与“干细胞”或“乳腺肿瘤”相关的基因列表。用户还可以从感兴趣的基因或途径入手，并确定与该基因或途径相关的作者，一项功能，可以更轻松地确定可能充当协作者或审阅者的专家。总之，BioLitMine通过提供一种健壮且以基因为中心的方法来检索相关信息，从而扩展了PubMed索引文献及其现有专家管理的价值。