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NTS and VTA oxytocin reduces food motivation and food seeking
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology ( IF 2.8 ) Pub Date : 2020-10-07 , DOI: 10.1152/ajpregu.00201.2020
Hallie S Wald 1 , Ananya Chandra 1 , Anita Kalluri 1 , Zhi Yi Ong 2 , Matthew R Hayes 3 , Harvey J Grill 1
Affiliation  

Oxytocin (OT) is a neuropeptide whose central receptor-mediated actions include reducing food intake. One mechanism of its behavioral action is the amplification of the feeding inhibitory effects of gastrointestinal (GI) satiation signals processed by hindbrain neurons. OT treatment also reduces carbohydrate intake in humans and rodents and correspondingly, deficits in central OT receptor (OT-R) signaling increase sucrose self-administration. This suggests that additional processes contribute to central OT effects on feeding. This study investigated the hypothesis that central OT reduces food intake by decreasing food seeking and food motivation. As central OT-Rs are expressed widely, a related focus was to assess the role of one or more OT-R expressing nuclei in food motivation and food seeking behavior. OT was delivered to the lateral ventricle (LV), nucleus tractus solitarius (NTS) or ventral tegmental area (VTA) and a progressive ratio (PR) schedule of operant reinforcement and an operant reinstatement paradigm were used to measure motivated feeding behavior and food seeking behavior, respectively. OT delivered to the LV, NTS or VTA reduced [1] motivation to work for food and [2] reinstatement of food-seeking behavior. Results provide a novel and additional interpretation for central OT-driven food intake inhibition to include the reduction of food motivation and food seeking.

中文翻译:

NTS 和 VTA 催产素减少食物动机和食物寻求

催产素 (OT) 是一种神经肽,其中枢受体介导的作用包括减少食物摄入。其行为作用的一种机制是后脑神经元处理的胃肠 (GI) 饱食信号的摄食抑制作用的放大。OT 治疗还减少了人类和啮齿动物的碳水化合物摄入量,相应地,中枢 OT 受体 (OT-R) 信号传导的缺陷会增加蔗糖的自我给药。这表明额外的过程有助于中央 OT 对喂养的影响。本研究调查了中央 OT 通过减少食物寻求和食物动机来减少食物摄入的假设。由于中心 OT-R 被广泛表达,相关的重点是评估一个或多个 OT-R 表达核在食物动机和食物寻求行为中的作用。OT 被输送到侧脑室 (LV)、孤束核 (NTS) 或腹侧被盖区 (VTA) 和操作性强化的渐进比率 (PR) 计划和操作性恢复范式用于测量动机喂养行为和食物寻求行为,分别。传送到 LV、NTS 或 VTA 的 OT 降低了 [1] 为食物工作的动机和 [2] 恢复觅食行为。结果为中枢 OT 驱动的食物摄入抑制提供了一种新的和额外的解释,包括减少食物动机和食物寻求。传送到 LV、NTS 或 VTA 的 OT 降低了 [1] 为食物工作的动机和 [2] 恢复觅食行为。结果为中枢 OT 驱动的食物摄入抑制提供了一种新的和额外的解释,包括减少食物动机和食物寻求。传送到 LV、NTS 或 VTA 的 OT 降低了 [1] 为食物工作的动机和 [2] 恢复觅食行为。结果为中枢 OT 驱动的食物摄入抑制提供了一种新的和额外的解释,包括减少食物动机和食物寻求。
更新日期:2020-10-08
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