In this work, a comparison study was conducted on the contents of total flavonoids and hyperoside in different polarity extracts of Fructus rosae laxae (FRL). The lipid‐lowering effect and mechanism of FRL ethyl acetate extract (FRLE) on the lipid accumulation model of Bel‐7402 cells in vitro were studied. The results showed that the contents of total flavonoids and hyperoside in FRLE were significantly higher than those in the other polarity extracts. Compared with those in the model group, the levels of triglyceride and total cholesterol decreased, the activities of superoxide dismutase and lactate dehydrogenase increased, and the levels of inflammatory factors interleukin‐6 and tumor necrosis factor‐α decreased significantly in the cells intervened with FRLE. Moreover, FRLE can regulate lipid metabolism by activating the AMP‐activated protein kinase α phosphorylation pathway and increasing the expression of adiponectin.

中文翻译：

---

红景天提取物刺激ADPN /AMPKα信号减弱Bel‐7402细胞脂质蓄积

在这项工作中，进行了一项比较研究，研究了五味子（FRL）不同极性提取物中总黄酮和高丝苷的含量。研究了FRL乙酸乙酯提取物（FRLE）对Bel-7402细胞体外脂质蓄积模型的降脂作用及其机理。结果表明，FRLE中总黄酮和高丝苷的含量明显高于其他极性提取物中的含量。与模型组相比，FRLE干预的细胞中甘油三酯和总胆固醇水平降低，超氧化物歧化酶和乳酸脱氢酶活性增加，炎性因子白细胞介素-6和肿瘤坏死因子-α水平明显降低。 。此外，