Seasonal influenza spreads during winter in temperate countries. Primary viral pneumoniae resulting from aggravation triggers acute respiratory distress syndrome, which is a serious respiratory disorder. We have identified a unique pattern of lung microbiota in patients with the syndrome. In this study, we hypothesized that the unique microbiota was also associated with primary influenza viral pneumoniae. Bacterial culture supernatants of Streptococcus oralis and Streptococcus mitis detected from the patients significantly increased viral replication (maximum 10-fold increase) in lung epithelial cells. Our results suggest that the lung environment microbiota is significantly involved in viral replication.

季节性流感在温带国家的冬季传播。由加重引起的原发性病毒性肺炎引发急性呼吸窘迫综合征，这是一种严重的呼吸系统疾病。我们已经确定了该综合征患者的肺微生物群的独特模式。在这项研究中，我们假设独特的微生物群也与原发性流感病毒性肺炎有关。从患者身上检测到的口腔链球菌和缓和链球菌的细菌培养上清液显着增加了肺上皮细胞中的病毒复制（最多增加了 10 倍）。我们的结果表明，肺环境微生物群显着参与病毒复制。