Contact dermatitis to personal care products is increasing (but different!) in males and females: North American Contact Dermatitis Group data, 1996-2016,Journal of the American Academy of Dermatology

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Contact dermatitis to personal care products is increasing (but different!) in males and females: North American Contact Dermatitis Group data, 1996-2016
Journal of the American Academy of Dermatology ( IF 13.8 ) Pub Date : 2020-10-08 , DOI: 10.1016/j.jaad.2020.10.003
Erin M Warshaw ₁ , Jamie P Schlarbaum ₂ , Jonathan I Silverberg ₃ , Joel G DeKoven ₄ , Anthony F Fransway ₅ , James S Taylor ₆ , Howard I Maibach ₇ , Joseph F Fowler ₈ , Amber R Atwater ₉ , Margo J Reeder ₁₀ , Kathryn A Zug ₁₁ , Donald V Belsito ₁₂ , Denis Sasseville ₁₃ , Vincent A DeLeo ₁₄ , Melanie D Pratt ₁₅

Affiliation

Department of Dermatology, Park Nicollet Health Services, Minneapolis, Minnesota; Department of Dermatology, University of Minnesota, Minneapolis, Minnesota; Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota.
Department of Dermatology, Park Nicollet Health Services, Minneapolis, Minnesota; Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota; University of Minnesota Medical School, Minneapolis, Minnesota.
Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC.
Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Associates in Dermatology, Fort Myers, Florida.
Department of Dermatology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio.
Department of Dermatology, University of California San Francisco, San Francisco, California.
University of Louisville, Louisville, Kentucky.
Department of Dermatology, Duke University, Durham, North Carolina.
Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
Department of Dermatology, Columbia University Irving Medical Center, New York, New York.
Division of Dermatology, Montreal General Hospital, McGill University, Montreal, Quebec, Canada.
Department of Dermatology, Keck School of Medicine, Los Angeles, California.
Division of Dermatology, University of Ottawa, Ontario, Canada.

Background

Personal care products (PCPs) are commonly responsible for allergic contact dermatitis and irritant contact dermatitis. PCP use was historically associated with females, but male-targeted PCPs are increasingly being marketed.

Objective

To characterize and compare males with PCP-related contact dermatitis (MPCPs) and females with PCP-related contact dermatitis (FPCPs).

Methods

This was a retrospective cross-sectional analysis of North American Contact Dermatitis Group data (1996-2016).

Results

Four thousand six hundred eighty of 16,233 men (28.8%) and 12,730 of 32,222 (39.5%) women had a PCP identified as a source of irritant contact dermatitis or a positive patch test reaction. The proportion of PCP-related dermatitis in both sexes significantly increased (>2.7-fold) over the decade of study. Compared with FPCPs, a larger proportion of MPCPs were older or had trunk or extremity dermatitis (P < .0001). MPCPs were twice as likely to have soaps as a source while FPCPs were twice as likely to have hair care products (P < .0001). The most common PCP-related North American Contact Dermatitis Group allergens for both sexes were methylisothiazolinone (MPCP 28.8% and FPCP 21.5%), fragrance mix I (MPCP 22.3% and FPCP 20.1%), balsam of Peru (MPCP 18.5% and FPCP 14.1%), quaternium-15 (MPCP 16.1% and FPCP 12.3%), and paraphenylenediamine (MPCP 11.5% and FPCP 11.1%).

Limitations

Patient population referred for suspected contact dermatitis.

Conclusions

PCP-related dermatitis is increasing. Sites of involvement and relevant PCP sources are distinct between sexes. Male and female variation in exposure history may explain differences in reactivity to some allergen groups.

中文翻译：

男性和女性的个人护理产品接触性皮炎正在增加（但不同！）：北美接触性皮炎组数据，1996-2016

背景

个人护理产品 (PCP) 通常会导致过敏性接触性皮炎和刺激性接触性皮炎。从历史上看，PCP 的使用与女性有关，但针对男性的 PCP 越来越多地被推向市场。

客观的

表征和比较患有 PCP 相关接触性皮炎 (MPCP) 的男性和患有 PCP 相关接触性皮炎 (FPCP) 的女性。

方法

这是对北美接触性皮炎组数据 (1996-2016) 的回顾性横断面分析。

结果

16,233 名男性中有 4,680 名 (28.8%) 和 32,222 名 (39.5%) 女性中有 12,730 名 PCP 被确定为刺激性接触性皮炎或斑贴试验阳性反应的来源。在十年的研究中，两性中与 PCP 相关的皮炎的比例显着增加（>2.7 倍）。与 FPCP 相比，更大比例的 MPCP 年龄较大或患有躯干或四肢皮炎（P < .0001）。MPCP 使用肥皂的可能性是其两倍，而 FPCP 使用护发产品的可能性是其两倍（P < .0001)。北美接触性皮炎组男女最常见的与 PCP 相关的过敏原是甲基异噻唑啉酮（MPCP 28.8% 和 FPCP 21.5%）、香料混合物 I（MPCP 22.3% 和 FPCP 20.1%）、秘鲁香脂（MPCP 18.5% 和 FPCP 14.1 %)、quaternium-15 (MPCP 16.1% 和 FPCP 12.3%) 和对苯二胺 (MPCP 11.5% 和 FPCP 11.1%)。