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Microfluidics for Medical Additive Manufacturing
Engineering ( IF 12.8 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.eng.2020.10.001
Jie Wang , Changmin Shao , Yuetong Wang , Lingyun Sun , Yuanjin Zhao

Abstract Additive manufacturing plays a vital role in the food, mechanical, pharmaceutical, and medical fields. Within these fields, medical additive manufacturing has led to especially obvious improvements in medical instruments, prostheses, implants, and so forth, based on the advantages of cost-effectiveness, customizability, and quick manufacturing. With the features of precise structural control, high throughput, and good component manipulation, microfluidic techniques present distinctive benefits in medical additive manufacturing and have been applied in the areas of drug discovery, tissue engineering, and organs on chips. Thus, a comprehensive review of microfluidic techniques for medical additive manufacturing is useful for scientists with various backgrounds. Herein, we review recent progress in the development of microfluidic techniques for medical additive manufacturing. We evaluate the distinctive benefits associated with microfluidic technologies for medical additive manufacturing with respect to the fabrication of droplet/fiber templates with different structures. Extensive applications of microfluidic techniques for medical additive manufacturing are emphasized, such as cell guidance, three-dimensional (3D) cell culture, tissue assembly, and cell-based therapy. Finally, we present challenges in and future perspectives on the development of microfluidics for medical additive manufacturing.

中文翻译:

用于医疗增材制造的微流体

摘要 增材制造在食品、机械、制药和医疗领域发挥着至关重要的作用。在这些领域中,基于成本效益、可定制性和快速制造的优势,医疗增材制造在医疗器械、假肢、植入物等方面取得了特别明显的进步。微流控技术具有结构控制精确、产量高、元件操作好等特点,在医疗增材制造中具有独特的优势,并已应用于药物发现、组织工程和芯片器官等领域。因此,对用于医疗增材制造的微流体技术的全面回顾对具有不同背景的科学家很有用。在此处,我们回顾了用于医疗增材制造的微流体技术开发的最新进展。我们评估了与医疗增材制造微流体技术相关的独特优势,涉及制造具有不同结构的液滴/纤维模板。强调了微流体技术在医疗增材制造中的广泛应用,例如细胞引导、三维 (3D) 细胞培养、组织组装和基于细胞的治疗。最后,我们提出了用于医疗增材制造的微流体技术发展的挑战和未来前景。我们评估了与医疗增材制造微流体技术相关的独特优势,涉及制造具有不同结构的液滴/纤维模板。强调了微流体技术在医疗增材制造中的广泛应用,例如细胞引导、三维 (3D) 细胞培养、组织组装和基于细胞的治疗。最后,我们提出了用于医疗增材制造的微流体技术发展的挑战和未来前景。我们评估了与医疗增材制造微流体技术相关的独特优势,涉及制造具有不同结构的液滴/纤维模板。强调了微流体技术在医疗增材制造中的广泛应用,例如细胞引导、三维 (3D) 细胞培养、组织组装和基于细胞的治疗。最后,我们提出了用于医疗增材制造的微流体技术发展的挑战和未来前景。
更新日期:2020-11-01
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