The aim of this study was to assess the effects of commonly used anaesthetics alfaxalone and propofol on salivary and urinary cortisol in healthy cats. Fifteen male castrated research-purposed cats received randomly intravenous continuous rate infusions of 8 mg/kg/h of alfaxalone, 12 mg/kg/h of propofol and 2 ml/kg/h of Lactated Ringer's solution for 30 min, with intervals of 6 days between treatments. Saliva samples were collected for 24 h before each infusion and for 24 h from the start of each infusion. Urine was collected as single pooled samples over each 24 h period. Mean integrated saliva cortisol responses in cats treated with alfaxalone were greater than responses of cats treated with propofol (P = 0.034) and controls (P = 0.017). Integrated responses in cats treated with propofol did not differ from controls. The mean urinary cortisol/creatinine ratio (UCCR) was higher on the day of treatment than the day before treatment in cats treated with alfaxalone (P < 0.0001) and in cats treated with propofol (P = 0.0168) and did not differ between days in cats treated with lactated Ringer's solution. The mean UCCR was higher in cats treated with alfaxalone than in cats treated with lactated Ringer's solution (P = 0.0020) on the day of treatment. Mean total urinary cortisol over 24 h was greater in cats treated with alfaxalone than controls (P = 0.0267). In conclusion, alfaxalone increased short-term salivary and urinary cortisol concentrations in healthy cats as compared to propofol and a control group of non-anesthetised cats.

本研究的目的是评估常用麻醉剂阿法沙酮和丙泊酚对健康猫唾液和尿皮质醇的影响。15 只雄性去势研究目的猫接受随机静脉连续输注 8 mg/kg/h 阿法沙酮、12 mg/kg/h 丙泊酚和 2 ml/kg/h 乳酸林格氏液 30 分钟，间隔为 6治疗之间的天数。每次输注前 ​​24 小时和每次输注开始后 24 小时收集唾液样品。每 24 小时收集尿液作为单一混合样品。阿法沙酮治疗的猫的平均综合唾液皮质醇反应高于丙泊酚治疗的猫（P = 0.034）和对照组（P= 0.017）。用丙泊酚治疗的猫的综合反应与对照组没有区别。阿法沙酮治疗的猫（P < 0.0001）和丙泊酚治疗的猫（P = 0.0168）在治疗当天的平均尿皮质醇/肌酐比值（UCCR）高于治疗前一天，并且在治疗天数之间没有差异用乳酸林格氏液治疗的猫。在治疗当天，用阿法沙酮治疗的猫的平均 UCCR 高于用乳酸林格氏液治疗的猫（P = 0.0020）。用阿法沙酮治疗的猫在 24 小时内的平均总尿皮质醇高于对照组（P= 0.0267）。总之，与丙泊酚和非麻醉猫对照组相比，阿法沙酮增加了健康猫的短期唾液和尿皮质醇浓度。