Abstract

A novel class of substituted quinolines was synthesized through a one-pot, four-component sequential reaction by intramolecular C–H activation of isocyanides with N-sulfonylamidines, catalyzed by copper(I) iodide and l-proline as a ligand in acetonitrile at room temperature. The readily available starting materials, no need for column chromatography, mild catalytic conditions, and moderate to high yields are important features of this simple one-pot reaction.

Graphic abstract

中文翻译：

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N-磺酰lam胺和异氰酸酯的分子内CH活化反应合成功能化喹啉衍生物

摘要

通过一锅四组分顺序反应，通过碘化亚铜和碘化脯氨酸作为室内配体，在碘化亚铜和1-脯氨酸的催化下，通过一锅四组分顺序反应，通过N-磺酰lam胺对异氰酸酯的分子内CH活化，合成了一类新的取代喹啉温度。这种简单的一锅反应的重要特征是易于获得的起始原料，无需柱色谱，温和的催化条件以及中等至高收率。

图形摘要