Abstract

The mechanism of the interaction of six sulfur-nitrosyl iron complexes capable of releasing nitric oxide as a result of the spontaneous hydrolytic decomposition with a erythrocyte suspension is studied. A kinetic model of the process, which includes reactions of the NO released from the complex into the solution, the NO interaction with oxyhemoglobin within the erythrocyte and dissolved oxygen, and the adsorption of complexes on the surface of erythrocytes, is proposed. The values of the kinetic parameters are determined. The developed model quantitatively describes the experimental data on the accumulation of methemoglobin (the product of the interaction of oxyhemoglobin with nitric oxide) obtained at different concentrations of the studied complexes and erythrocytes in the system.

中文翻译：

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一氧化氮供体与红细胞相互作用过程的动力学模型

摘要

研究了六种硫-亚硝酰铁配合物的相互作用机理，这些配合物由于自发的水解分解与红细胞悬浮液而释放出一氧化氮。提出了该过程的动力学模型，包括从配合物释放到溶液中的NO的反应，NO与红细胞内的氧合血红蛋白和溶解氧的相互作用以及配合物在红细胞表面的吸附。确定动力学参数的值。所开发的模型定量描述了在不同浓度的研究复合物和系统中获得的高铁血红蛋白（氧合血红蛋白与一氧化氮相互作用的产物）积累的实验数据。