Priority data have been obtained on the effects of repeated systemic administrations of water-dispersible single-walled carbon nanotubes (SWCNTs) to spontaneously hypertensive rats with respect to constitutive NO-synthase (cNOS). As is known, NO is an inhibitory transmitter in the cardiovascular system. It was found that the systemic (i.p., subcutaneous, and i.m.) introductions of SWCNTs during two weeks resulted in considerable elevations of the NO2– level (a marker of NO bioavailability) in the blood of experimental hypertensive animals. Thus, SWCNTs may be used in the future for antihypertensive therapy as a novel agent capable of activating cNOS and, thus, increasing the NO production in central and peripheral elements of the cardiovascular system.

中文翻译：

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水分散性单壁碳纳米管的全身给药：在自发性高血压大鼠中激活 NOS

已获得关于水分散性单壁碳纳米管 (SWCNT) 对自发性高血压大鼠重复全身给药对组成型 NO 合酶 (cNOS) 的影响的优先数据。众所周知，NO是心血管系统中的抑制性递质。结果发现，在两周内全身（腹腔注射、皮下和肌内注射）引入 SWCNT 会导致实验性高血压动物血液中的 NO2– 水平（NO 生物利用度的标志物）显着升高。因此，SWCNTs 可能在未来作为一种能够激活 cNOS 的新型药物用于抗高血压治疗，从而增加心血管系统中枢和外周部分的 NO 产生。