The wound healing process is characterized by varied biological and molecular cascades including inflammation, tissue proliferation, and remodeling phase. To augment and maintain these cascades, an all-natural matrix system is proposed. Biocompatible biopolymers, sodium alginate and gelatin, were employed to prepare microfibers via extrusion-gelation into a physical crosslinking solution. Curcumin, an anti-inflammatory, anti-oxidant and wound healing agent, was loaded into the fibers as a natural bioactive compound. Curcumin-loaded composite microfibers and blank microfibers were fabricated using biopolymers such as sodium alginate and gelatin. The formulation batches were coded as A1G9-A10G0 according to the varied concentrations of sodium alginate and gelatin. The molecular transitions within the composite microfibers were characterized using FTIR and were further corroborated using molecular mechanics analysis. In mechanical properties tensile strength and elongation-at-break (extensibility) were ranging between 1.08 ± 0.01 to 3.53 ± 0.41 N/mm² and 3.89 ± 0.18 to 0.61 ± 0.03%. The morphological analysis confirmed the formation and fabrication of the microfibers. In addition, physical evaluation including matrix degradation and entrapment efficiency was performed to give a comparative account of various formulations. The water uptake capacity of the blank and curcumin-loaded composite fibers was found to be in the range of 30.77 ± 2.17 to 100.00 ± 5.99 and 22.34 ± 1.11 to 56.34 ± 4.68, respectively. Composite microfibers presented a cumulative release of 85% in 72 h, confirming the prolonged release potential of the composite fibers. The drug release followed an anomalous (non-Fickian) release behavior asserting the role of degradation and diffusion. In an in vivo full-thickness cutaneous wound model, the composite microfibers provided higher degree of contraction 96.89 ± 3.76% as compared to the marketed formulation (Vicco turmeric cream). In conclusion, this all-natural, alginate–gelatin–curcumin composite has the potential to be explored as a cost-effective wound healing platform.

伤口愈合过程的特点是各种生物和分子级联反应，包括炎症、组织增殖和重塑阶段。为了增加和维护这些级联，提出了一种全自然矩阵系统。生物相容性生物聚合物，海藻酸钠和明胶，被用来通过挤出凝胶化成物理交联溶液来制备微纤维。姜黄素是一种抗炎、抗氧化剂和伤口愈合剂，作为天然生物活性化合物被加载到纤维中。加载姜黄素的复合微纤维和空白微纤维是使用海藻酸钠和明胶等生物聚合物制造的。根据不同浓度的海藻酸钠和明胶，配方批次被编码为A1G9-A10G0。复合微纤维内的分子转变使用 FTIR 进行表征，并使用分子力学分析进一步证实。在机械性能方面，拉伸强度和断裂伸长率（延展性）范围在 1.08 ± 0.01 至 3.53 ± 0.41 N/mm 之间²和 3.89 ± 0.18 至 0.61 ± 0.03%。形态分析证实了微纤维的形成和制造。此外，还进行了包括基质降解和包封率在内的物理评估，以对各种配方进行比较。发现空白和加载姜黄素的复合纤维的吸水能力分别在 30.77 ± 2.17 至 100.00 ± 5.99 和 22.34 ± 1.11 至 56.34 ± 4.68 的范围内。复合微纤维在 72 小时内的累积释放率为 85%，证实了复合纤维的延长释放潜力。药物释放遵循异常（非菲克）释放行为，表明降解和扩散的作用。在体内全层皮肤伤口模型中，复合微纤维提供了更高的收缩度 96.89 ± 3。76% 与市售配方（Vicco 姜黄奶油）相比。总之，这种全天然的海藻酸盐-明胶-姜黄素复合材料有可能成为一种具有成本效益的伤口愈合平台。