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Synthesis of mesoporous silicate molecular sieves by the aerosol-assisted method for loading and release of drug
Royal Society Open Science ( IF 3.5 ) Pub Date : 2020-10-07 , DOI: 10.1098/rsos.200650
Liang Hao 1 , Xiaojia Li 1 , Yang Wang 1
Affiliation  

The mesoporous silicate molecular sieves were synthesized with polyether F127 as the template by the aerosol-assisted method for loading and release of ibuprofen (IBU). The synthesized samples were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and N2 adsorption–desorption isotherms. The drug IBU was applied as a model drug to investigate the drug release behaviour by ultraviolet spectrophotometry measurements. The investigation results demonstrate that mesoporous silicate molecular sieves by the aerosol-assisted method are spherical with a core–shell structure. As the drug carrier, it has good structural stability and can achieve drug controlled release which is expected. It exhibits safety to a certain degree. Therefore, the aerosol-assisted synthesis method provides a new idea for the synthesis of sustained-release drug carriers.



中文翻译:

气溶胶辅助法合成中孔硅酸盐分子筛

以聚醚F127为模板,通过气溶胶辅助法合成布洛芬(IBU)的介孔硅酸盐分子筛。通过扫描电子显微镜,透射电子显微镜,X射线衍射和N 2表征合成的样品。吸附-解吸等温线。将药物IBU用作模型药物,以通过紫外分光光度法测量研究药物的释放行为。研究结果表明,采用气溶胶辅助法的中孔硅酸盐分子筛是球形的,具有核-壳结构。作为药物载体,它具有良好的结构稳定性,可以实现预期的药物控制释放。它在一定程度上显示出安全性。因此,气溶胶辅助合成方法为合成缓释药物载体提供了新思路。

更新日期:2020-10-07
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