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Copper-catalyzed functionalization of enynes
Chemical Science ( IF 8.4 ) Pub Date : 2020-10-07 , DOI: 10.1039/d0sc04012f Quentin Dherbassy 1, 2, 3, 4 , Srimanta Manna 1, 2, 3, 4 , Fabien J. T. Talbot 1, 2, 3, 4 , Watcharapon Prasitwatcharakorn 1, 2, 3, 4 , Gregory J. P. Perry 1, 2, 3, 4 , David J. Procter 1, 2, 3, 4
Chemical Science ( IF 8.4 ) Pub Date : 2020-10-07 , DOI: 10.1039/d0sc04012f Quentin Dherbassy 1, 2, 3, 4 , Srimanta Manna 1, 2, 3, 4 , Fabien J. T. Talbot 1, 2, 3, 4 , Watcharapon Prasitwatcharakorn 1, 2, 3, 4 , Gregory J. P. Perry 1, 2, 3, 4 , David J. Procter 1, 2, 3, 4
Affiliation
The copper-catalyzed functionalization of enyne derivatives has recently emerged as a powerful approach in contemporary synthesis. Enynes are versatile and readily accessible substrates that can undergo a variety of reactions to yield densely functionalized, enantioenriched products. In this perspective, we review copper-catalyzed transformations of enynes, such as boro- and hydrofunctionalizations, copper-mediated radical difunctionalizations, and cyclizations. Particular attention is given to the regiodivergent functionalization of 1,3-enynes, and the current mechanistic understanding of such processes.
中文翻译:
铜催化的炔烃官能化
烯炔衍生物的铜催化功能化最近已成为当代合成中的一种有力方法。烯炔是通用且易于获得的底物,其可以进行多种反应以生成高密度官能化,对映体富集的产品。从这个角度出发,我们回顾了炔烃的铜催化转化,例如硼和氢官能化,铜介导的自由基双官能化和环化。特别注意1,3-烯炔的区域扩散功能化,以及目前对这种过程的机械理解。
更新日期:2020-10-19
中文翻译:
铜催化的炔烃官能化
烯炔衍生物的铜催化功能化最近已成为当代合成中的一种有力方法。烯炔是通用且易于获得的底物,其可以进行多种反应以生成高密度官能化,对映体富集的产品。从这个角度出发,我们回顾了炔烃的铜催化转化,例如硼和氢官能化,铜介导的自由基双官能化和环化。特别注意1,3-烯炔的区域扩散功能化,以及目前对这种过程的机械理解。