Aim: Blood–brain barrier (BBB) disruption is the primary initiating cause of cerebral small-vessel diseases including leukoaraiosis (LA). β-Catenin is a key regulator of the BBB and plays an important role in cell–cell adhesion at adherens junctions by interacting with cadherin molecules. Thus, β-Catenin may be a good candidate gene for LA. We performed a genetic analyses to investigate the association between β-catenin alleles and LA.

中文翻译：

---

Wnt信号通路基因（β-连环蛋白）的遗传变异与白血球病易感性的关联

目的：血脑屏障（BBB）的破坏是脑白质疏松症（LA）等脑小血管疾病的主要起因。β-Catenin是BBB的关键调节剂，通过与钙粘蛋白分子的相互作用在粘附连接的细胞间粘附中发挥重要作用。因此， β-连环蛋白可能是LA的良好候选基因。我们进行了一项遗传分析，以研究β-连环蛋白等位基因与LA之间的关联。