Bioceramics have experienced great development over the past 50 years. Modern bioceramics are designed to integrate bioactive ions within ceramic granules to trigger living tissue regeneration. Preclinical and clinical studies have shown that strontium is a safe and effective divalent metal ion for preventing osteoporosis, which has led to its incorporation in calcium phosphate-based ceramics. The local release of strontium ions during degradation results in moderate concentrations that trigger osteogenesis with few systemic side effects. Moreover, strontium has been proven to generate a favorable immune environment and promote early angiogenesis at the implantation site. Herein, the important aspects of strontium-enriched calcium phosphate bioceramics (Sr-CaPs), and how Sr-CaPs affect the osteogenic microenvironment, are described.

中文翻译：

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用锶取代的磷酸钙陶瓷构建成骨微环境

生物陶瓷在过去的 50 年里经历了巨大的发展。现代生物陶瓷旨在将生物活性离子整合到陶瓷颗粒中以触发活组织再生。临床前和临床研究表明，锶是一种安全有效的二价金属离子，可用于预防骨质疏松症，这导致它被纳入磷酸钙基陶瓷中。降解过程中锶离子的局部释放导致中等浓度的锶离子触发骨生成，几乎没有全身副作用。此外，锶已被证明可以产生有利的免疫环境并促进植入部位的早期血管生成。在此，描述了富含锶的磷酸钙生物陶瓷 (Sr-CaPs) 的重要方面，以及 Sr-CaPs 如何影响成骨微环境。