The injury to the spinal cord is among the most complex fields of medical development. Spinal cord injury (SCI) leads to acute loss of motor and sensory function beneath the injury level and is linked to a dismal prognosis. Currently, while a strategy that could heal the injured spinal cord remains unforeseen, the latest advancements in polymer-mediated approaches demonstrate promising treatment forms to remyelinate or regenerate the axons and to integrate new neural cells in the SCI. Moreover, they possess the capacity to locally deliver synergistic cells, growth factors (GFs) therapies and bioactive substances, which play a critical role in neuroprotection and neuroregeneration. Here, we provide an extensive overview of the SCI characteristics, the pathophysiology of SCI, and strategies and challenges for the treatment of SCI in a review. This review highlights the recent encouraging applications of polymer-based scaffolds in developing the novel SCI therapy.

中文翻译：

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基于聚合物的脊髓修复和再生支架策略

脊髓损伤是医学发展中最复杂的领域之一。脊髓损伤 (SCI) 导致损伤水平以下的运动和感觉功能急性丧失，并与预后不良有关。目前，虽然可以治愈受伤脊髓的策略仍然无法预见，但聚合物介导方法的最新进展证明了有希望的治疗形式来使轴突再生或再生，并将新的神经细胞整合到 SCI 中。此外，它们具有局部递送协同细胞、生长因子 (GF) 疗法和生物活性物质的能力，这些物质在神经保护和神经再生中起着关键作用。在这里，我们在综述中广泛概述了 SCI 的特征、SCI 的病理生理学以及治疗 SCI 的策略和挑战。