Abstract Sensor technology has become increasingly crucial in medical research and clinical diagnostics to directly detect small numbers of low-molecular-weight biomolecules relevant for lethal diseases. In recent years, various technologies have been developed, a number of them becoming core label-free technologies for detection of cancer biomarkers and viruses. However, to radically improve early disease diagnostics, tracking of disease progression and evaluation of treatments, today’s biosensing techniques still require a radical innovation to deliver high sensitivity, specificity, diffusion-limited transport, and accuracy for both nucleic acids and proteins. In this review, we discuss both scientific and technological aspects of hyperbolic dispersion metasurfaces for molecular biosensing. Optical metasurfaces have offered the tantalizing opportunity to engineer wavefronts while its intrinsic nanoscale patterns promote tremendous molecular interactions and selective binding. Hyperbolic dispersion metasurfaces support high-k modes that proved to be extremely sensitive to minute concentrations of ultralow-molecular-weight proteins and nucleic acids.

中文翻译：

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用于分子生物传感的双曲色散超表面

摘要 传感器技术在医学研究和临床诊断中变得越来越重要，可以直接检测与致命疾病相关的少量低分子量生物分子。近年来，已经开发了各种技术，其中一些技术成为检测癌症生物标志物和病毒的核心无标记技术。然而，为了从根本上改善早期疾病诊断、疾病进展跟踪和治疗评估，今天的生物传感技术仍然需要彻底创新，以提供核酸和蛋白质的高灵敏度、特异性、扩散限制运输和准确性。在这篇综述中，我们讨论了用于分子生物传感的双曲色散超表面的科学和技术方面。光学超表面为设计波前提供了诱人的机会，而其固有的纳米级图案促进了巨大的分子相互作用和选择性结合。双曲线色散超表面支持高 k 模式，该模式被证明对极低浓度的超低分子量蛋白质和核酸极为敏感。