The ability of the cells to sense mechanical cues is an integral component of ”social” cell behavior inside tissues with a complex architecture. Through ”mechanosensation” cells are in fact able to decrypt motion, geometries and physical information of surrounding cells and extracellular matrices by activating intracellular pathways converging onto gene expression circuitries controlling cell and tissue homeostasis. Additionally, only recently cell mechanosensation has been integrated systematically as a crucial element in tissue pathophysiology. In the present review, we highlight some of the current efforts to assess the relevance of mechanical sensing into pathology modeling and manufacturing criteria for a next generation of cardiovascular tissue implants.

中文翻译：

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在下一代心血管组织工程中利用机械感觉

细胞感知机械线索的能力是具有复杂结构的组织内“社会”细胞行为的一个组成部分。通过“机械感觉”，细胞实际上能够通过激活会聚到控制细胞和组织稳态的基因表达回路的细胞内通路来解密周围细胞和细胞外基质的运动、几何形状和物理信息。此外，直到最近，细胞机械感觉才被系统地整合为组织病理生理学中的一个关键要素。在本综述中，我们强调了当前为评估机械传感与下一代心血管组织植入物的病理建模和制造标准的相关性所做的一些努力。