Neurological symptoms are seen in patients with COVID-19 and can persist or re-emerge after clearance of SARS-CoV-2. Recent findings suggest that antibodies to SARS-CoV-2 can cross-react with mammalian proteins. Focusing on neurological symptoms, we discuss whether these cross-reactive antibodies could contribute to COVID-19 disease pathology and to the persistence of symptoms in patients who have cleared the initial viral infection. Neurological symptoms are increasingly being observed in patients with COVID-19; this Comment article considers whether cross-reactive antibodies might contribute to the pathology associated with SARS-CoV-2 infection.

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交叉反应抗体会引起 COVID-19 的神经病理学吗？

神经系统症状见于 COVID-19 患者，并且在 SARS-CoV-2 清除后可能持续存在或重新出现。最近的研究结果表明，SARS-CoV-2 抗体可以与哺乳动物蛋白发生交叉反应。我们重点关注神经系统症状，讨论这些交叉反应抗体是否可能导致 COVID-19 疾病病理学以及清除初始病毒感染的患者症状持续存在。在 COVID-19 患者中越来越多地观察到神经系统症状；这篇评论文章考虑了交叉反应抗体是否可能导致与 SARS-CoV-2 感染相关的病理学。