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Association of E-Selectin gene polymorphisms and serum E-Selectin level with risk of coronary artery disease in lur population of Iran
Archives of Physiology and Biochemistry ( IF 3 ) Pub Date : 2020-10-06 , DOI: 10.1080/13813455.2020.1828481
Mobin Khoshbin 1, 2 , Seyyed Amir Yasin Ahmadi 3 , Mostafa Cheraghi 1, 4 , Negar Nouryazdan 2 , Mehdi Birjandi 5 , Gholamreza Shahsavari 1, 2
Affiliation  

Abstract

Background

Adhesion molecules like E-selectin have important role in pathogenesis of atherosclerosis. C1901T and G98T polymorphisms of E-selectin gene and E-selectin serum level may affect the risk of coronary artery disease (CAD).

Methods

A total of 145 normal individuals and 154 patients diagnosed with CAD from the Lur population of Iran undergoing coronary angiography were enrolled. Genetic polymorphisms of E-selectin were determined using PCR-RFLP. Serum level of soluble E-selectin was measured using Elisa.

Results

T allele in C1901T polymorphism was significantly associated with an increased risk of atherosclerosis (P = 0.018). No significant association was observed for G98T polymorphism. The mean serum level of soluble E-selectin in the patient group was significantly higher than the control group (P < 0.001).

Conclusions

Allele type in C1901T polymorphism plays a role in increasing the risk of developing CAD. Furthermore, since serum E-selectin level is associated with systemic inflammation, it contributes to the increased risk of the disease.



中文翻译:

E-Selectin 基因多态性和血清 E-Selectin 水平与伊朗 lur 人群冠状动脉疾病风险的关联

摘要

背景

E-选择素等粘附分子在动脉粥样硬化的发病机制中具有重要作用。E-选择素基因C1901TG98T多态性及E-选择素血清水平可能影响冠状动脉疾病(CAD)的风险。

方法

共有 145 名正常人和 154 名来自伊朗 Lur 人群的 CAD 患者接受了冠状动脉造影术。使用 PCR-RFLP 确定E-选择素的遗传多态性。使用 Elisa 测量可溶性 E-选择素的血清水平。

结果

C1901T多态性中的 T 等位基因与动脉粥样硬化风险增加显着相关 ( P  = 0.018)。G98T多态性未观察到显着关联。患者组血清可溶性 E-选择素平均水平显着高于对照组(P  < 0.001)。

结论

C1901T多态性中的等位基因类型在增加患 CAD 的风险中起作用。此外,由于血清 E-选择素水平与全身炎症有关,因此它会增加患该病的风险。

更新日期:2020-10-06
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