Neddylation is one type of protein post-translational modification by conjugating a ubiquitin-like protein neural precursor cell-expressed developmentally downregulated protein 8 to substrate proteins via a cascade involving E1, E2, and E3 enzymes. The best-characterized substrates of neddylation are cullins, essential components of cullin-RING E3 ubiquitin–ligase complexes. The discovery of noncullin neddylation targets indicates that neddylation may have diverse biological functions. Indeed, neddylation has been implicated in various cellular processes including cell cycle progression, metabolism, immunity, and tumorigenesis. Here, we summarized the reported neddylation substrates and also discuss the functions of neddylation in the immune system and metabolism.

中文翻译：

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neddylation 在代谢和免疫中的多样化和关键作用

Neddylation 是一种蛋白质翻译后修饰，通过涉及 E1、E2 和 E3 酶的级联将泛素样蛋白质神经前体细胞表达发育下调蛋白质 8 与底物蛋白质结合。neddylation 的最佳表征底物是cullins，cullin-RING E3 泛素-连接酶复合物的基本成分。noncullin neddylation 目标的发现表明neddylation 可能具有多种生物学功能。事实上，neddylation 与各种细胞过程有关，包括细胞周期进程、代谢、免疫和肿瘤发生。在这里，我们总结了已报道的 neddylation 底物，并讨论了 neddylation 在免疫系统和新陈代谢中的功能。