The interaction between ingested xenobiotics and the gastrointestinal epithelium influences the possibility of gut epithelial cytotoxicity and systemic toxicity. Potassium bromate (KBrO₃) has been shown to perturb the central nervous system and it may be carcinogenic, albeit it is used as a food additive. This highlights the need to understand KBrO₃’s effect on the stomach epithelium. Here, we report the cytotoxic potential of KBrO₃ in an ulcerated stomach, as well as possible cytoprotection by the polyphenol ‒ protocatechuic acid. Potassium bromate (12.5 mg/kg) and protocatechuic acid (120 mg/kg) were administered orally while omeprazole (20 mg/kg) was used as standard. Potassium bromate exacerbated gastric ulcers, increased malonaldehyde levels, catalase, and sodium pump activities, but reduced nitric oxide levels. Potassium bromate further increased mast cell count in the muscularis mucosa, while inducing chronic inflammation and moderate angiogenesis in the gastric mucosa. Our results delineate KBrO₃‐induced gastric epithelial cytotoxicity that is ameliorated by protocatechuic acid.

中文翻译：

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慢性胃溃疡Wister大鼠模型中溴酸钾的细胞毒性：原儿茶酸可能逆转

摄入的异种生物与胃肠道上皮之间的相互作用影响肠道上皮细胞毒性和全身毒性的可能性。溴酸钾（KBrO ₃）已被证明会扰乱中枢神经系统，尽管它被用作食品添加剂，但仍可能致癌。这强调了需要了解KBrO ₃对胃上皮细胞的作用。在这里，我们报告KBrO ₃的细胞毒性潜力在溃疡的胃中，以及多酚phenol原儿茶酸的可能的细胞保护作用。口服施用溴酸钾（12.5 mg / kg）和原儿茶酸（120 mg / kg），而奥美拉唑（20 mg / kg）用作标准。溴酸钾加重了胃溃疡，丙二醛水平，过氧化氢酶和钠泵活性增加，但一氧化氮水平降低。溴酸钾进一步增加了肌层粘膜中肥大细胞的数量，同时在胃粘膜中诱导了慢性炎症和中度血管生成。我们的结果描述了原儿茶酸可改善KBrO ₃诱导的胃上皮细胞毒性。