The present randomized, double‐blinded, placebo‐controlled study investigated the effect of a standardized fenugreek extract (FHE) on perimenopausal discomforts and its influence on hormonal balance and safety. Healthy women characterized with perimenopausal symptoms (n = 48), as assessed by MRS questionnaire, were randomized either to FHE (n = 24) or placebo (n = 24) and supplemented with 250 mg × 2/day for 42 days. Both inter and intra‐group comparison revealed a significant improvement in somatic, psychological, and urogenital scores in FHE group, especially for hot flashes (25.9%), night sweats (26.5%), depression (31.8%), and insomnia (21.6%). Further hormone analysis revealed an enhancement in serum estradiol (18.9%), free testosterone (38.2%), and progesterone (19.9%) concentrations and a significant decrease in FSH (38.2%) and SHBG (21.1%) concentrations toward establishing a hormonal balance among FHE‐group; without significant changes in other clinical safety parameters. Thus, FHE supplementation offered a significant reduction in vasomotor effects and depression in perimenopausal women, without any adverse effects

中文翻译：

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一种新的胡芦巴种子提取物在缓解围绝经期妇女血管舒缩症状和抑郁症方面的功效：一项随机、双盲、安慰剂对照研究

本随机、双盲、安慰剂对照研究调查了标准化胡芦巴提取物 (FHE) 对围绝经期不适的影响及其对荷尔蒙平衡和安全性的影响。根据 MRS 问卷评估，具有围绝经期症状 ( n  = 48) 的健康女性被随机分配至 FHE ( n  = 24) 或安慰剂组 ( n = 24) 并补充 250 mg × 2/天，持续 42 天。组间和组内比较均显示 FHE 组的躯体、心理和泌尿生殖系统评分显着改善，尤其是潮热 (25.9%)、盗汗 (26.5%)、抑郁 (31.8%) 和失眠 (21.6%) ）。进一步的激素分析显示血清雌二醇 (18.9%)、游离睾酮 (38.2%) 和孕酮 (19.9%) 浓度增加，FSH (38.2%) 和 SHBG (21.1%) 浓度显着降低，以建立激素平衡FHE组中；其他临床安全参数没有显着变化。因此，FHE 补充剂显着降低了围绝经期妇女的血管舒缩作用和抑郁症，而没有任何副作用