Two novel epimerized andrographolides, 8,17‐dihydro‐7,8‐dehydroandrographolide and 10β‐8,17‐dihydro‐7,8‐dehydroandrographolide, were isolated from andrographolide sulfonates. Their structures were elucidated by detailed NMR analysis, single‐crystal X‐ray diffraction and quantum chemical ECD calculations. In addition, these compounds exhibited suppression of NO production in LPS‐stimulated RAW264.7 cells over the range of 1.564 to 25.000 μg/mL.

中文翻译：

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两种具有抗炎和细胞毒活性的新型穿心莲内酯

从穿心莲内酯磺酸盐中分离出两种新型差向异构化穿心莲内酯，8,17-二氢-7,8-脱氢穿心莲内酯和10β-8,17-二氢-7,8-脱氢穿心莲内酯。通过详细的核磁共振分析、单晶 X 射线衍射和量子化学 ECD 计算阐明了它们的结构。此外，这些化合物在 LPS 刺激的 RAW264.7 细胞中表现出抑制 NO 产生的作用，范围为 1.564 至 25.000 μg/mL。