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Maternal known drug allergy and long‐term dermatological morbidity of the offspring
American Journal of Reproductive Immunology ( IF 3.6 ) Pub Date : 2020-10-06 , DOI: 10.1111/aji.13356
Ariel Noy 1 , Tamar Wainstock 2 , Eyal Sheiner 3 , Tom Leibson 4, 5 , Amir Horev 6 , Gali Pariente 3
Affiliation  

Drug allergy is associated with adverse short‐term perinatal outcomes such as caesarian delivery and preterm delivery. The aim of the present study was to determine whether being born to a mother with known drug allergy increases the risk for long‐term dermatological morbidity of the offspring. A population‐based cohort study, comparing long‐term dermatological morbidity of offspring to mothers with and without known drug allergy, was conducted. Dermatological morbidity was assessed up to the age of 18 years according to a predefined set of ICD‐9 codes associated with hospitalization of the offspring. A Kaplan‐Meier survival curve was used to compare cumulative incidence of long‐term dermatological morbidity, and a Cox proportional hazards model was constructed to control of confounders. During the study period, 243,682 deliveries met the inclusion criteria, of them 4% (n = 9756) were of mothers with known drug allergy. Offspring born to mothers with known drug allergy had higher rates of long‐term dermatological morbidity Likewise, the cumulative incidence of long‐term dermatological morbidity was higher as compared with those without known drug allergy (Kaplan‐Meier log‐rank P = .021). Using a Cox proportional hazards model, controlling for confounders, being born to a mother with known drug allergy was found to be an independent risk factor for long‐term dermatological morbidity of the offspring (adjusted HR 1.2, 95% CI 1.03‐1.33, P = .016). Being born to a mother with known drug allergy is independently associated with higher risk for long‐term dermatological morbidity of the offspring.

中文翻译:

母亲已知的药物过敏和后代的长期皮肤病发病率

药物过敏与不良的短期围产期结局有关,例如剖腹产和早产。本研究的目的是确定已知药物过敏的母亲所生的孩子是否会增加后代长期皮肤病发病率的风险。进行了一项基于人群的队列研究,比较了后代与已知药物过敏和无已知药物过敏的母亲的长期皮肤病发病率。根据与后代住院相关的一组预定义的 ICD-9 代码,评估了 18 岁之前的皮肤病发病率。Kaplan-Meier 生存曲线用于比较长期皮肤病发病率的累积发生率,并构建 Cox 比例风险模型来控制混杂因素。在研究期间,243,682 次分娩符合纳入标准,其中 4% (n = 9756) 是已知药物过敏的母亲。已知药物过敏的母亲所生的后代长期皮肤病发病率较高同样,长期皮肤病发病率的累积发生率高于没有已知药物过敏的母亲(Kaplan-Meier log-rankP  = .021)。使用 Cox 比例风险模型,控制混杂因素,发现已知药物过敏的母亲所生是后代长期皮肤病发病率的独立危险因素(调整后的 HR 1.2,95% CI 1.03-1.33,P  = .016)。已知药物过敏的母亲所生与后代长期皮肤病发病率较高的风险独立相关。
更新日期:2020-10-06
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