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A spraying applicator device is not required for efficacy of a live intranasal respiratory vaccine in young calves, which improves user convenience
Veterinary Immunology and Immunopathology ( IF 1.8 ) Pub Date : 2020-10-07 , DOI: 10.1016/j.vetimm.2020.110130
Piet Nuijten 1 , Jeroen van der Loop 1 , Mark van Rooij 1 , Birgit Makoschey 1 , Geert Vertenten 1
Affiliation  

Almost all bovine intranasal respiratory vaccines require a spraying device, but there are no published reports which prove the necessity of this. The objective of this investigation was to compare the efficacy of the Bovilis® INtranasal RSP™ Live vaccine when applied with or without an (intra)nasal spraying device. This vaccine contains live, attenuated strains of bovine respiratory syncytial virus (BRSV) and bovine parainfluenza virus type 3 (BPI3V) and is licensed to protect young cattle against respiratory infections with wild-type field isolates of these viruses.

Two efficacy studies, for BRSV and BPI3V respectively, were performed in which the vaccine was administered using a spraying device or directly from the tip of a syringe as a liquid stream.

Both BRSV-vaccinated groups showed a reduction of nasal shedding, BRSV titres in lung washings and clinical symptoms. The BPI3V vaccinated groups showed a significant reduction of nasal shedding and a non-significant reduction of clinical symptoms. Overall, in both studies, the groups in which vaccine was administered without the spraying device performed better than the groups with the spraying device, although this difference was not statistically significant.

In conclusion, a spraying device to administer Bovilis® INtranasal RSP™ Live was not required and both application methods induced a protective immune response. This makes application more convenient and flexible for future users and animals.



中文翻译:

幼小牛鼻内呼吸道活疫苗的功效不需要喷洒器,可提高使用者的便利性

几乎所有的牛鼻内呼吸道疫苗都需要喷洒装置,但是没有公开的报告证明这样做的必要性。这项研究的目的是比较Bovilis®INtranasal RSP™Live疫苗在有或没有鼻内喷雾装置时的功效。该疫苗包含牛呼吸道合胞病毒(BRSV)和3型牛副流感病毒(BPI3V)的减毒活菌株,并被许可使用这些病毒的野生型野外分离株来保护幼牛免受呼吸道感染。

进行了分别针对BRSV和BPI3V的两项功效研究,其中使用喷雾装置或直接从注射器尖端以液流形式施用疫苗。

两组BRSV疫苗接种组均显示鼻腔脱落,肺洗液BRSV滴度降低和临床症状减少。BPI3V疫苗接种组的鼻腔脱落明显减少,临床症状无明显减少。总体而言,在两项研究中,没有喷雾装置的疫苗接种组的效果均优于带有喷雾装置的组,尽管这一差异在统计学上并不显着。

总之,不需要使用Bovilis®INtranasal RSP™Live的喷雾装置,并且两种施用方法均可以诱导保护性免疫应答。这使应用程序对于将来的用户和动物来说更加方便和灵活。

更新日期:2020-10-14
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