Protein phosphatase type 1 (PP1) forms a wide range of Ser/Thr-specific phosphatase holoenzymes which contain one catalytic subunit (PP1c), present in all eukaryotic cells, associated with variable subunits known as regulatory proteins. It has recently been shown that regulators take a leading role in the organization and the control of PP1 functions. Many studies have addressed the role of these regulators in diverse organisms, including humans, and investigated their link to diseases. In this review we summarize recent advances on the role of PP1c in Plasmodium, its interactome and regulators. As a proof of concept, peptides interfering with the regulator binding capacity of PP1c were shown to inhibit the growth of P. falciparum, suggesting their potential as drug precursors.

1型蛋白磷酸酶（PP1）形成了一系列Ser / Thr特异性磷酸酶全酶，这些酶含有一个存在于所有真核细胞中的催化亚基（PP1c），与称为调节蛋白的可变亚基相关。最近显示，监管机构在PP1功能的组织和控制中起着领导作用。许多研究已经探讨了这些调节剂在包括人类在内的多种生物中的作用，并研究了它们与疾病的联系。在这篇综述中，我们总结了PP1c在疟原虫，其相互作用基因组和调节剂中的作用的最新进展。作为概念的证明，干扰PP1c的调节子结合能力的肽显示抑制恶性疟原虫的生长，表明它们作为药物前体的潜力。