Abstract Biosurfactants – tensioactive biometabolites – are currently preferred over their synthetic counterparts due to some unique properties such as sustainable production, eco-compatibility, and low cytotoxicity, among others. Among different biosurfactant groups currently known, the microbial-derived glycolipids (MGLs) are of growing interests in the formulation of biomedical and cosmetic products due to their structural diversities, antimicrobial properties, stability under harsh environmental conditions, and functional versatility. While the usefulness of the MGLs in biomedical and cosmetics fields cannot be overemphasized, their commercial competitiveness has been restrained due to a myriad of bottlenecks which include poor product yields and high cost of production associated with downstream processing. Herein, we reviewed the importance of process economics in MGLs production to project strategies needed for product competitiveness in terms of yields and cost which will favour their global market. The significance of techno-economic assessment in translating laboratory-based data to commercial-scale MGL production was underlined. The strategies adopted by commercial MGL-producing firms to enhance the market value of their products were also presented. Finally, the future of MGLs in the surfactant market is highlighted.

中文翻译：

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生物医学和个人护理产品可持续配方中的微生物衍生糖脂：对商业化过程经济性的考虑

摘要 生物表面活性剂——表面活性生物代谢物——由于具有一些独特的特性，如可持续生产、生态相容性和低细胞毒性等，目前比其合成对应物更受欢迎。在目前已知的不同生物表面活性剂组中，微生物来源的糖脂 (MGL) 由于其结构多样性、抗菌性能、在恶劣环境条件下的稳定性和功能多功能性，在生物医学和化妆品的配方中越来越受到关注。尽管 MGL 在生物医学和化妆品领域的用途再怎么强调也不为过，但由于产品产量低和与下游加工相关的生产成本高昂等无数瓶颈，它们的商业竞争力受到了限制。在此处，我们回顾了过程经济学在 MGLs 生产中的重要性，以规划产品在产量和成本方面的竞争力所需的战略，这将有利于他们的全球市场。强调了技术经济评估在将实验室数据转化为商业规模 MG​​L 生产方面的重要性。还介绍了商业 MGL 生产公司为提高其产品的市场价值而采用的策略。最后，强调了表面活性剂市场中 MGL 的未来。还介绍了商业 MGL 生产公司为提高其产品的市场价值而采用的策略。最后，强调了表面活性剂市场中 MGL 的未来。还介绍了商业 MGL 生产公司为提高其产品的市场价值而采用的策略。最后，强调了表面活性剂市场中 MGL 的未来。