Abstract Bioadhesive polymeric hydrogels capable of firm adhesion to various biological tissues have acquired considerable attention due to their significance in medicine and dentistry. Thus far many types of bioadhesive hydrogels have been investigated using different polymers such as polyacrylates, poly(ethylene glycol)s, and the derivatives of polysaccharides and proteins, while less attention has been paid to polyamphoteric properties of cross-linked polymer networks. The aim of this study is to investigate the bioadhesive properties of polyamphoteric hydrogels synthesized by copolymerizing acrylic acid with N,N-dimethylaminopropyl acrylamide in the presence of N,N′-methylenebisacrylamide. Tissue adhesion of hydrated gels was evaluated in vitro using the excised porcine intestine as a substrate, and the data were compared with that measured for the pure poly(acrylic acid) hydrogel that is a bioadhesive system extensively studied ever. In this study, it is demonstrated that the incorporation of a small fraction of the cationic monomer to a poly(acrylic acid) hydrogel gives rise to the formation of polyamphoteric hydrogels that exhibit firm adhesion toward mucosa. The results of the mechanistic study revealed that the adhesion enhancement by cation incorporation is primarily due to the increased density of carboxylic acids that are capable of interacting with mucosal components. Furthermore, it was suggested that the dynamic behaviors of the polymer segments have an additional effect on the enhanced mucoadhesion.

中文翻译：

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由丙烯酸和 N,N-二甲氨基丙基丙烯酰胺合成的聚两性水凝胶的黏膜粘附

摘要 能够牢固粘附于各种生物组织的生物粘附聚合物水凝胶因其在医学和牙科方面的重要性而受到广泛关注。迄今为止，已经使用不同的聚合物（例如聚丙烯酸酯、聚（乙二醇）以及多糖和蛋白质的衍生物）研究了多种类型的生物粘附水凝胶，而对交联聚合物网络的两性性质关注较少。本研究的目的是研究丙烯酸与 N,N-二甲基氨基丙基丙烯酰胺在 N,N'-亚甲基双丙烯酰胺存在下共聚合成的聚两性水凝胶的生物粘附性能。使用切除的猪肠作为基质在体外评估了水合凝胶的组织粘附，并将数据与纯聚（丙烯酸）水凝胶测量的数据进行比较，后者是一种广泛研究的生物粘附系统。在这项研究中，证明将一小部分阳离子单体掺入聚（丙烯酸）水凝胶会形成聚两性水凝胶，其对粘膜具有牢固的粘附力。机理研究的结果表明，通过阳离子掺入增强粘附力主要是由于能够与粘膜成分相互作用的羧酸密度增加。此外，有人提出聚合物链段的动态行为对增强的粘膜粘附有额外的影响。结果表明，将一小部分阳离子单体掺入聚（丙烯酸）水凝胶中会形成聚两性水凝胶，该水凝胶对粘膜具有牢固的粘附性。机理研究的结果表明，阳离子掺入的粘附增强主要是由于能够与粘膜成分相互作用的羧酸密度增加。此外，有人提出聚合物链段的动态行为对增强的粘膜粘附有额外的影响。结果表明，将一小部分阳离子单体掺入聚（丙烯酸）水凝胶中会形成聚两性水凝胶，该水凝胶对粘膜具有牢固的粘附性。机理研究的结果表明，阳离子掺入的粘附增强主要是由于能够与粘膜成分相互作用的羧酸密度增加。此外，有人提出聚合物链段的动态行为对增强的粘膜粘附有额外的影响。机理研究的结果表明，阳离子掺入的粘附增强主要是由于能够与粘膜成分相互作用的羧酸密度增加。此外，有人提出聚合物链段的动态行为对增强的粘膜粘附有额外的影响。机理研究的结果表明，阳离子掺入的粘附增强主要是由于能够与粘膜成分相互作用的羧酸密度增加。此外，有人提出聚合物链段的动态行为对增强的粘膜粘附有额外的影响。