In this study, the etherification of glycerol was executed with dodecanol through use of homogeneous catalysts. First, a univariate study of direct condensation was executed to determine the effects of the variables reaction time, catalyst type and glycerol:dodecanol molar ratio on the dodecyl ether (DOE) and glyceryl monododecyl ether (GMDE) production. A full 2³ factorial design was used to evaluate the effect of glycerol:dodecanol molar ratio, catalyst loading and temperature on the production of dodecyl ether (DOE), glyceryl monododecyl ether (GMDE) substituted on carbon 1 (C1) or carbon 2 (C2). The GMDE yield was 35% in 3 h. The experimental results indicated that rising temperature positively affected GMDE content and higher catalyst loading increased DOE production. In the case of traditional routes, Williamson synthesis produced just 5% GMDE while when applying solketal synthesis, high yield and purity of this compound were obtained, demonstrating the viability of GMDE production.

在这项研究中，甘油的醚化是通过使用均相催化剂与十二烷醇进行的。首先，进行了直接缩合的单变量研究，以确定变量反应时间，催化剂类型和甘油：十二烷醇摩尔比对十二烷基醚（DOE）和甘油单十二烷基醚（GMDE）生产的影响。整场2 ³析因设计用于评估甘油：十二烷醇的摩尔比，催化剂的加入量和温度对十二碳醚（DOE），碳1（C1）或碳2（C2）上取代的甘油单十二烷基醚（GMDE）生产的影响。3小时内的GMDE产率为35％。实验结果表明，温度升高对GMDE含量有积极影响，而较高的催化剂负载量则增加了DOE的产生。在传统路线的情况下，Williamson合成仅产生5％的GMDE，而当采用溶胶状合成时，该化合物的收率和纯度均很高，证明了GMDE的可行性。