A multicomponent reaction was used as a synthetic strategy to prepare organotin (IV) complexes, 2-amino-3-hydroxypyridine, saliciladehydes 5-R-substituted (H, CH₃, OCH₃, C(CH)₃, F, Cl, Br, I, NO₂), and dibutyltin(IV) oxide were used as starting materials. The complexes were analyzed by IR, UV–Visible, MS, NMR of ¹H, ¹³C, ¹¹⁹Sn. The complex 3a was structurally identified by X-ray crystallography, which revealed a dimeric arrangement where the tin atom possess a distorted hexacoordinated environment in which the deprotonated phenolic oxygen atoms and the nitrogen atom of the azomethine from the ligand are coordinated to the metallic center, and one of the phenoxy oxygens bridges with the tin through an intermolecular interaction forming a planar Sn₂O₂ core. As strategy of molecular design, isosteric and bioisosteric replacement of halogens were employed. All organotin compounds were assessed for their in vitro cytotoxic activity on cancer cell lines K‐562 (chronic myelogenous leukemia), U‐251 (glioblastoma), HCT‐15 (human colorectal cancer), MCF‐7, MDA-MB-231 (human breast cancer), and SKLU‐1 (non‐small‐cell lung cancer). They evidenced an elevated cytotoxic activity, and the inhibitory percentage values stated higher activity than the cis-platin. The K-562 and MDA-MB-231 cells were more sensitive to organotin (IV) complexes than HCT-15 and MCF-7. The organotin (IV) compounds were also tested in vivo for brine shrimp lethality to examine their toxic properties.

使用多组分反应作为合成策略来制备有机锡（IV）配合物，2-氨基-3-羟基吡啶，水杨醛5-R取代的（H，CH ₃，OCH ₃，C（CH）₃，F，Cl，使用Br，I，NO ₂）和二丁基氧化锡（IV）作为起始原料。通过IR，UV-Visible，MS，¹ H，¹³ C，¹¹⁹ Sn的NMR进行分析。复杂3a通过X射线晶体学在结构上进行了鉴定，发现了一种二聚体排列，其中锡原子具有扭曲的六配位环境，其中来自配体的去质子化的酚氧原子和偶氮甲碱的氮原子配位至金属中心，苯氧通过分子间相互作用与锡桥连，形成平面Sn ₂ O ₂核心。作为分子设计的策略，采用了等位和生物等位取代卤素。评估了所有有机锡化合物对癌细胞系K-562（慢性粒细胞性白血病），U-251（胶质母细胞瘤），HCT-15（人结肠直肠癌），MCF-7，MDA-MB-231（人类乳腺癌）和SKLU-1（非小细胞肺癌）。他们证明了细胞毒活性的提高，抑制百分率值表明其活性高于顺铂。与HCT-15和MCF-7相比，K-562和MDA-MB-231细胞对有机锡（IV）复合物更敏感。还对体内的有机锡（IV）化合物进行了盐水虾致死性测试，以检查其毒性。