Gastric cancer is the most typical oncological illness globally. Though the incidence of gastric cancer has dropped dramatically over the last few years, the survival rate is yet concerning due to poor diagnostic strategy. The etiology of gastric cancer is majorly associated with dietary factors. For this reason, application of nontoxic natural agents with anticancer effects for patients is needed. Diosmin has been commonly utilized to treat various diseases both traditionally and now clinically. However, its effect on gastric carcinogenesis remains unclear. The effects of diosmin were used to evaluate how N-methyl-N-nitrosourea (MNU) induces gastric carcinogenesis in rats. The general and gross assessment of MNU in experimental animals was tabulated. Biological tumor markers (gastrin, ALP, LDH, and γ-GT) were examined. Oxidative markers (LPO) and antioxidative markers (GSH, vitamin E, and vitamin C) were determined. In addition, inflammatory cytokines (thioredoxin, glutaredoxin, NF-κB, TNF-α, IL-6, PGE2) were explored and justified with histopathological studies. Overall, the results showed positive anticancer activity demonstrated by improved body weight, reduced tumor rate, decreased oxidative marker value by increased antioxidative rate, and suppressed tumor biomarkers and inflammatory cytokines. The histopathological analysis was congruent with the data observed. Our conclusion that diosmin exerts its anticancer activity by up-regulation of antioxidants which might be responsible for amelioration of oxidative stress and inflammatory cytokines in carcinogenesis to prevent gastric cancer.

中文翻译：

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薯皂甙调节大鼠N-甲基-N-亚硝基脲诱导的胃癌发生中的氧化应激和炎症标志物水平

胃癌是全球最典型的肿瘤疾病。尽管最近几年胃癌的发病率急剧下降，但由于诊断策略不佳，其存活率仍令人担忧。胃癌的病因主要与饮食因素有关。因此，需要对患者使用具有抗癌作用的无毒天然药物。在传统上和现在临床上，薯os皂素已普遍用于治疗各种疾病。然而，其对胃癌发生的作用尚不清楚。用薯os皂甙的效果来评估N-甲基-N亚硝基脲（MNU）诱导大鼠胃癌发生。将实验动物中MNU的一般评估和总体评估制成表格。检查了生物学肿瘤标志物（胃泌素，ALP，LDH和γ-GT）。确定了氧化标记（LPO）和抗氧化标记（GSH，维生素E和维生素C）。此外，探索了炎性细胞因子（硫氧还蛋白，谷胱甘肽毒素，NF-κB，TNF-α，IL-6，PGE2）并通过组织病理学研究证明其合理性。总体而言，结果显示出积极的抗癌活性，表现为体重增加，肿瘤率降低，抗氧化率提高，氧化标志物值降低以及肿瘤生物标志物和炎症细胞因子的抑制。组织病理学分析与观察到的数据一致。