Abstract Binge eating disorder (BED) increasingly affects population, but the mechanisms of the disease and its biomarkers are not well characterized. Recently, plasma purines, pyrimidines, amino acid and nicotinamide metabolites profiling attracted attention in studies on pathology and biomarkers of mental disorders but has not been adequately studied in BED. Blood and plasma samples were taken from patients with adult obese with BED (n = 20) and control adult obese without BED (n = 17). Plasma samples were analyzed for nucleotides and amino acid concentrations with high-performance liquid chromatography-mass spectrometry. BED had a significantly (p < 0.05) lower uridine and hypoxanthine to creatinine ratio compared to the control group. Among the amino acids BED patients had significantly (p < 0.05) lower concentrations of glutamic acid, leucine, isoleucine and the whole branched-chain amino acids group, while the concentration of citrulline was increased. Among nicotinamide metabolites, 1-methylnicotinamide levels were significantly (p < 0.05) lower. This study highlights potential use of profiling nucleotide metabolite and amino acid pattern in BED patients that may provide information on mechanisms and potential biomarkers. However, further investigation in larger population is necessary to identify clinical correlates of the observed changes.

中文翻译：

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暴食症和肥胖症患者血浆核苷酸代谢物和氨基酸模式的比较

摘要 暴食症 (BED) 越来越多地影响人群，但该疾病的机制及其生物标志物尚未得到很好的表征。最近，血浆嘌呤、嘧啶、氨基酸和烟酰胺代谢物分析引起了精神障碍病理学和生物标志物研究的关注，但尚未在 BED 中得到充分研究。血液和血浆样本取自患有 BED 的成人肥胖患者 (n = 20) 和无 BED 的对照成人肥胖患者 (n = 17)。用高效液相色谱-质谱法分析血浆样品的核苷酸和氨基酸浓度。与对照组相比，BED​​ 具有显着（p < 0.05）较低的尿苷和次黄嘌呤与肌酐的比率。在氨基酸中，BED 患者的谷氨酸浓度显着（p < 0.05）较低，亮氨酸、异亮氨酸和整个支链氨基酸组，而瓜氨酸的浓度增加。在烟酰胺代谢物中，1-甲基烟酰胺水平显着降低（p < 0.05）。这项研究强调了在 BED 患者中分析核苷酸代谢物和氨基酸模式的潜在用途，这可能提供有关机制和潜在生物标志物的信息。然而，需要在更大的人群中进行进一步调查，以确定观察到的变化的临床相关性。这项研究强调了在 BED 患者中分析核苷酸代谢物和氨基酸模式的潜在用途，这可能提供有关机制和潜在生物标志物的信息。然而，需要在更大的人群中进行进一步调查，以确定观察到的变化的临床相关性。这项研究强调了在 BED 患者中分析核苷酸代谢物和氨基酸模式的潜在用途，这可能提供有关机制和潜在生物标志物的信息。然而，需要在更大的人群中进行进一步调查，以确定观察到的变化的临床相关性。