ABSTRACT

Introduction

COVID-19 disease has shocked the world by its spread and contagiousness. At this time, there is no valid vaccine and no proven drug treatment for COVID-19 patients. Current treatments are focused on Oxygenation, Cytokine Storm management, anti-inflammatory effects, and antiviral therapy. Antiviral photodynamic therapy (aPDT) is based on the reaction between a photo-sensitive agent and a light source in the presence of oxygen which can produce oxidative and free radical agents to damage the virus’ structures. Recent studies show that nanotechnology can improve aPDT’s outcome. The aim of this study was to find out the potential therapeutic effects of Nano antiviral photodynamic therapy on COVID-19.

Areas covered

This review evaluates Nano Antiviral Photodynamic Therapy: A Probable Biophysicochemical Management Modality in SARS-CoV-2. Data were extracted from published different studies published on PUBMED, SCOPUS, and Web of Science.

Expert opinion

Studies indicating that aPDT and Nano-based aPDT can be useful in viral pulmonary complications like Influenza, SARS-CoV, and MERS, but there was no direct study on SARS-Cov-2. Recent studies showed that Nano-based aPDT could relate to control of the stages of viral infections. Altogether, further investigations for the application of nanomedicine in antimicrobial photodynamic inactivation are needed for COVID-19 Management.

中文翻译：

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纳米抗病毒光动力疗法：SARS CoV 2中可能的生物物理化学管理方式。

抽象的

介绍

COVID-19病的传播和传染性震惊了世界。目前，没有有效的疫苗，也没有针对COVID-19患者的经过验证的药物治疗。当前的治疗方法集中在氧合，细胞因子风暴管理，抗炎作用和抗病毒治疗上。抗病毒的光动力疗法（aPDT）是基于光敏剂和光源在氧气存在下的反应而产生的，氧气会产生氧化剂和自由基剂，从而破坏病毒的结构。最近的研究表明，纳米技术可以改善aPDT的结果。这项研究的目的是发现纳米抗病毒光动力疗法对COVID-19的潜在治疗作用。

覆盖区域

这篇评论评估纳米抗病毒光动力疗法：SARS冠状病毒2中可能的生物物理化学管理方式。数据摘自在PUBMED，SCOPUS和Web of Science上发表的不同研究。

专家意见

研究表明，aPDT和基于纳米的aPDT可以用于病毒性肺部并发症，如流感，SARS-CoV和MERS，但尚未对SARS-Cov-2进行直接研究。最近的研究表明，基于纳米的aPDT可能与病毒感染阶段的控制有关。总而言之，COVID-19管理需要进一步研究纳米药物在抗菌光动力灭活中的应用。