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The bio‐surfactant mannosylerythritol lipid acts as a selective antibacterial agent to modulate rumen fermentation
Animal Science Journal ( IF 2 ) Pub Date : 2020-10-05 , DOI: 10.1111/asj.13464
Kana Okuhira 1 , Satoshi Koike 1 , Shinji Ito 2 , Yasuo Kobayashi 1
Affiliation  

Methyl‐mannosylerythritol lipid (MEL), a new sugar esterified lipid synthesized by Pseudozyma aphidis, was assessed for its functionality in modulating rumen fermentation and microbiota toward more propionate and less methane production. A pure culture study using rumen representatives showed that MEL selectively inhibited the growth of most Gram‐positive bacteria including Streptococcus bovis, ruminococci, and Fibrobacter succinogenes, but not Gram‐negative bacteria such as Megasphaera elsdenii, Succinivibrio dextrinosolvens, and Selenomonas ruminantium. A batch culture study revealed that MEL significantly decreased methane production in a dose‐dependent manner with accumulation of hydrogen, while propionate production was enhanced. A continuous culture (Rusitec) study confirmed all of these changes. A feeding study revealed that sheep fed a MEL diet showed an increased proportion of propionate, while proportions of acetate and butyrate were decreased without affecting total VFA level. These changes disappeared after cessation of MEL feeding. Based on these results, dietary application of MEL can favorably modify rumen fermentation in terms of the efficiency of dietary energy utilization.

中文翻译:

生物表面活性剂甘露糖赤藓糖醇脂质作为选择性抗菌剂调节瘤胃发酵

甲基甘露糖基赤藓糖醇脂质 (MEL) 是一种由Pseudozyma aphidis合成的新型糖酯化脂质,评估了其在调节瘤胃发酵和微生物群以增加丙酸和减少甲烷产量方面的功能。使用瘤胃代表的纯培养研究表明,MEL 选择性地抑制大多数革兰氏阳性菌的生长,包括牛链球菌、瘤胃球菌和产琥珀酸纤维杆菌,但不抑制革兰氏阴性菌,如埃氏巨球菌溶解糊精琥珀弧菌和反刍硒单胞菌. 分批培养研究表明,随着氢气的积累,MEL 以剂量依赖的方式显着降低甲烷产量,同时丙酸产量增加。连续培养 (Rusitec) 研究证实了所有这些变化。一项喂养研究表明,喂食 MEL 日粮的绵羊丙酸比例增加,而乙酸和丁酸比例降低,但不影响总 VFA 水平。这些变化在停止 MEL 喂食后消失。基于这些结果,MEL 的日粮应用可以在日粮能量利用效率方面有利地改变瘤胃发酵。
更新日期:2020-10-06
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