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Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: An arterial spin labeling study
Human Brain Mapping ( IF 4.8 ) Pub Date : 2020-10-05 , DOI: 10.1002/hbm.25223
Song'an Shang 1 , Jingtao Wu 2 , Hongying Zhang 2 , Hongri Chen 2 , Zhengye Cao 2 , Yu-Chen Chen 1 , Xindao Yin 1
Affiliation  

Persisting asymmetry of motor symptoms are characteristic of Parkinson's disease (PD). We investigated the possible lateralized effects on regional cerebral blood flow (CBF), CBF‐connectivity, and laterality index (LI) among PD subtypes using arterial spin labeling (ASL). Forty‐four left‐sided symptom dominance patients (PDL), forty‐eight right‐sided symptom dominance patients (PDR), and forty‐five matched HCs were included. Group comparisons were performed for the regional normalized CBF, CBF‐connectivity and LI of basal ganglia (BA) subregions. The PDL patients had lower CBF in right calcarine sulcus and right supramarginal gyrus compared to the PDR and the HC subjects. Regional perfusion alterations seemed more extensive in the PDL than in the PDR group. In the PDL, correlations were identified between right thalamus and motor severity, between right fusiform gyrus and global cognitive performance. None of correlations survived after multiple comparisons correction. The significantly altered CBF‐connectivity among the three groups included: unilateral putamen, unilateral globus pallidus, and right thalamus. LI score in the putamen was significantly different among groups. Motor‐symptom laterality in PD may exhibit asymmetric regional and interregional abnormalities of CBF properties, particularly in PDL patients. This preliminary study underlines the necessity of classifying PD subgroups based on asymmetric motor symptoms and the potential application of CBF properties underlying neuropathology in PD.

中文翻译:

帕金森病运动不对称相关的脑灌注模式:动脉自旋标记研究

运动症状的持续不对称是帕金森病 (PD) 的特征。我们使用动脉自旋标记 (ASL) 研究了 PD 亚型之间可能对局部脑血流量 (CBF)、CBF 连接性和偏侧指数 (LI) 的影响。包括 44 名左侧症状优势患者 (PDL)、48 名右侧症状优势患者 (PDR) 和 45 名匹配的 HC。对基底神经节 (BA) 亚区的区域归一化 CBF、CBF 连接性和 LI 进行组比较。与 PDR 和 HC 受试者相比,PDL 患者右侧距状沟和右侧缘上回的 CBF 较低。PDL 的区域灌注改变似乎比 PDR 组更广泛。在 PDL 中,确定了右侧丘脑和运动严重程度之间的相关性,右梭状回与整体认知能力之间的关系。在多重比较校正后,没有一个相关性幸存下来。三组之间显着改变的 CBF 连接包括:单侧壳核、单侧苍白球和右侧丘脑。壳核中的 LI 评分在各组之间存在显着差异。PD 的运动症状偏侧性可能表现出 CBF 特性的不对称区域和区域间异常,尤其是在 PDL 患者中。这项初步研究强调了基于不对称运动症状对 PD 亚组进行分类的必要性,以及基于神经病理学的 CBF 特性在 PD 中的潜在应用。三组之间显着改变的 CBF 连接包括:单侧壳核、单侧苍白球和右侧丘脑。壳核中的 LI 评分在各组之间存在显着差异。PD 的运动症状偏侧性可能表现出 CBF 特性的不对称区域和区域间异常,尤其是在 PDL 患者中。这项初步研究强调了基于不对称运动症状对 PD 亚组进行分类的必要性,以及基于神经病理学的 CBF 特性在 PD 中的潜在应用。三组之间显着改变的 CBF 连接包括:单侧壳核、单侧苍白球和右侧丘脑。壳核中的 LI 评分在各组之间存在显着差异。PD 的运动症状偏侧性可能表现出 CBF 特性的不对称区域和区域间异常,尤其是在 PDL 患者中。这项初步研究强调了基于不对称运动症状对 PD 亚组进行分类的必要性,以及基于神经病理学的 CBF 特性在 PD 中的潜在应用。
更新日期:2020-10-05
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