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Effect of fluoride in drinking water on the level of 5-methylcytosine in human and rat blood
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-10-06 , DOI: 10.1016/j.etap.2020.103511
Xinyue Meng , Yingjie Yao , Yongzheng Ma , Nan Zhong , Sowanou Alphonse , Junrui Pei

DNA methylation is an epigenetic modification of genome that is involved in many human diseases. Recent studies revealed DNA methylation may be associated with fluorosis. This study was aimed to evaluate the dose-response effect of fluoride on DNA methylation in human and rat blood. A commercial ELISA kit was employed to evaluate 5-methylcytosine (5-mC) level of genome in human and rat blood. A total of 281 subjects were enrolled in this study and divided into four equal-size groups by the quartile of fluoride in drinking water. The difference of 5-mC among the four groups was significant. The U-shaped relationship was found between fluoride and 5-mC in the population. The U-shaped curve was also observed in the rats with three months of fluoride treatments. Taken together, these results clue the disruption of DNA methylation in mammals may has a certain association with fluoride in natural exposures.



中文翻译:

饮用水中的氟对人和大鼠血液中5-甲基胞嘧啶水平的影响

DNA甲基化是基因组的表观遗传修饰,涉及许多人类疾病。最近的研究表明,DNA甲基化可能与氟中毒有关。这项研究旨在评估氟化物对人和大鼠血液中DNA甲基化的剂量反应效应。使用商用ELISA试剂盒评估人和大鼠血液中基因组5-甲基胞嘧啶(5-mC)的水平。共有281名受试者参加了这项研究,并按饮用水中氟化物的四分位数将其分为四个相等大小的组。四组之间的5-mC差异显着。在人群中发现氟与5-mC之间呈U形关系。在三个月的氟化物治疗大鼠中也观察到了U形曲线。在一起

更新日期:2020-10-30
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