BACKGROUND Deep brain stimulation (DBS) is an effective therapy for reducing the motor symptoms of Parkinson's disease, but the mechanisms of action of DBS and neural correlates of symptoms remain unknown. OBJECTIVE To use the neural response to DBS to reveal connectivity of neural circuits and interactions between groups of neurons as potential mechanisms for DBS. METHODS We recorded activity evoked by DBS of the subthalamic nucleus (STN) in humans with Parkinson's disease. In follow up experiments we also simultaneously recorded activity in the contralateral STN or the ipsilateral globus pallidus from both internal (GPi) and external (GPe) segments. RESULTS DBS local evoked potentials (DLEPs) were stereotyped across subjects, and a biophysical model of reciprocal connections between the STN and the GPe recreated DLEPs. Simultaneous STN and GP recordings during STN DBS demonstrate that DBS evoked potentials were present throughout the basal ganglia and confirmed that DLEPs arose from the reciprocal connections between the STN and GPe. The shape and amplitude of the DLEPs were dependent on the frequency and duration of DBS and were correlated with resting beta band oscillations. In the frequency domain, DLEPs appeared as a 350 Hz high frequency oscillation (HFO) independent of the frequency of DBS. CONCLUSIONS DBS evoked potentials suggest that the intrinsic dynamics of the STN and GP are highly interlinked and may provide a promising new biomarker for adaptive DBS.

中文翻译：

---

诱发电位揭示了人类深部脑刺激所参与的神经回路

背景深部脑刺激(DBS) 是减轻帕金森病运动症状的有效疗法，但DBS 的作用机制和症状的神经相关性仍然未知。目的利用对 DBS 的神经反应来揭示神经回路的连通性和神经元组之间的相互作用，作为 DBS 的潜在机制。方法我们记录了帕金森病患者丘脑底核 (STN) 的 DBS 诱发的活动。在后续实验中，我们还同时记录了来自内部 (GPi) 和外部 (GPe) 节段的对侧 STN 或同侧苍白球的活动。结果 DBS 局部诱发电位 (DLEPs) 在受试者之间被定型，STN 和 GPe 之间相互联系的生物物理模型重新创建了 DLEP。STN DBS 期间同时进行 STN 和 GP 记录表明 DBS 诱发电位存在于整个基底神经节，并证实 DLEP 源自 STN 和 GPe 之间的相互连接。DLEP 的形状和幅度取决于 DBS 的频率和持续时间，并与静息 beta 波段振荡相关。在频域中，DLEP 表现为 350 Hz 的高频振荡 (HFO)，与 DBS 的频率无关。结论 DBS 诱发电位表明 STN 和 GP 的内在动力学高度相互关联，可能为适应性 DBS 提供有希望的新生物标志物。DLEP 的形状和幅度取决于 DBS 的频率和持续时间，并与静息 beta 波段振荡相关。在频域中，DLEP 表现为与 DBS 频率无关的 350 Hz 高频振荡 (HFO)。结论 DBS 诱发电位表明 STN 和 GP 的内在动力学高度相互关联，可能为适应性 DBS 提供有希望的新生物标志物。DLEP 的形状和幅度取决于 DBS 的频率和持续时间，并与静息 beta 波段振荡相关。在频域中，DLEP 表现为 350 Hz 的高频振荡 (HFO)，与 DBS 的频率无关。结论 DBS 诱发电位表明 STN 和 GP 的内在动力学高度相互关联，可能为适应性 DBS 提供有希望的新生物标志物。