Natural or synthetic materials designed to adhere to biological components, bioadhesives, have received significant attention in clinics and surgeries. As a result, there are several commercially available, FDA-approved bioadhesives used for skin wound closure, hemostasis, and sealing tissue gaps or cracks in soft tissues. Recently, the application of bioadhesives has been expanded to various areas including musculoskeletal tissue engineering and regenerative medicine. The instant establishment of a strong adhesion force on tissue surfaces has shown potential to augment repair of connective tissues. Bioadhesives have also been applied to secure tissue grafts to host bodies and to fill or seal gaps in musculoskeletal tissues caused by injuries or degenerative diseases. In addition, the injectability equipped with the instant adhesion formation may provide the great potential of bioadhesives as vehicles for localized delivery of cells, growth factors, and small molecules to facilitate tissue healing and regeneration. This review covers recent research progress in bioadhesives as focused on their applications in musculoskeletal tissue repair and regeneration. We also discuss the advantages and outstanding challenges of bioadhesives, as well as the future perspective toward regeneration of connective tissues with high mechanical demand.

旨在粘附生物成分、生物粘合剂的天然或合成材料在临床和手术中受到了极大的关注。因此，有几种市售的、经 FDA 批准的生物粘合剂用于皮肤伤口闭合、止血和密封软组织中的组织间隙或裂缝。最近，生物粘合剂的应用已扩展到各个领域，包括肌肉骨骼组织工程和再生医学。在组织表面上立即建立强粘附力已显示出增强结缔组织修复的潜力。生物粘合剂还被用于将组织移植物固定到宿主身上，并填充或密封由损伤或退行性疾病引起的肌肉骨骼组织中的间隙。此外，配备即时粘附形成的可注射性可以提供生物粘合剂作为细胞、生长因子和小分子局部递送载体的巨大潜力，以促进组织愈合和再生。本综述涵盖了生物粘合剂的最新研究进展，重点是它们在肌肉骨骼组织修复和再生中的应用。我们还讨论了生物粘合剂的优势和突出的挑战，以及具有高机械需求的结缔组织再生的未来前景。本综述涵盖了生物粘合剂的最新研究进展，重点是它们在肌肉骨骼组织修复和再生中的应用。我们还讨论了生物粘合剂的优势和突出的挑战，以及具有高机械需求的结缔组织再生的未来前景。本综述涵盖了生物粘合剂的最新研究进展，重点是它们在肌肉骨骼组织修复和再生中的应用。我们还讨论了生物粘合剂的优势和突出的挑战，以及具有高机械需求的结缔组织再生的未来前景。