In the “headache world,” great attention has always been paid to migraine patients, especially for the research and development of new therapies. For the other forms of primary headaches, especially those of Chapters 2 and 3 of the classification, there are however therapies that, even if not specific, can give significant results. Tension-type headache recognizes in NSAIDs the most effective drugs to treat acute attack, while prevention is based on the use of tricyclic antidepressants and muscle relaxants. For TACs, the discussion is more complex: first of all, there are two forms of primary headache that respond absolutely to indomethacin. For these, the main problem is how to manage the possible side effects arising from prolonged treatments and possibly what to use as an alternative. For cluster headaches and short-lasting unilateral neuralgiform headache attacks, we have drugs with good efficacy as regards medical therapy, such as verapamil or lamotrigine, but in recent years, neuromodulation techniques, both surgical and non-invasive, have also been affirming themselves, which represent a more possibility for forms of headache that are often very disabling and resistant to common analgesics.

在“头痛世界”中，偏头痛患者一直受到高度重视，特别是在新疗法的研发方面。对于其他形式的原发性头痛，尤其是该分类的第2章和第3章，有些疗法即使没有特效也可以产生明显的效果。紧张型头痛在非甾体抗炎药中公认是治疗急性发作的最有效药物，而预防则是基于三环类抗抑郁药和肌肉松弛药的使用。对于TAC，讨论更为复杂：首先，有两种形式的原发性头痛对吲哚美辛有绝对的反应。对于这些，主要问题是如何处理因长期治疗而引起的可能的副作用，以及可能用作替代方法的方法。