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Spasticity distribution and severity in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis
Journal of Neurovirology ( IF 3.2 ) Pub Date : 2020-10-06 , DOI: 10.1007/s13365-020-00911-7
Matheus Sales 1, 2 , Giselle Bárbara de Almeida Scaldaferri 1 , Juliana Iris Barbosa Dos Santos 1 , Ailton Melo 1, 3 , Nildo Manoel da Silva Ribeiro 1, 2, 4
Affiliation  

In individuals with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), spasticity is one of the main symptoms. The neurological signs of the disease are well defined, but details of how spasticity appears in these individuals have not been well explored. To describe spasticity location and severity of HAM/TSP individuals. Cross-sectional study with individuals older than 18 years, diagnosed with HAM/TSP and with lower limb spasticity. Pregnant women, individuals with other associated neurological diseases, and those using antispastic drugs were not included. Spasticity was assessed by the Modified Ashworth Scale (MAS), applied to the abductor, adductor, flexor, and extensor muscles of the hips, flexors, and extensors of the knees, dorsiflexors, plantiflexors, evertors, and inverters of the foot. Thirty participants were included. The plantiflexor muscles (90%), knee extensors (80%), knee flexors (63,3%), and adductors (50%) were most frequently affected by spasticity. Twenty-three (76.7%) individuals had mixed spasticity, 5 (16.7%) with distal spasticity and 2 (6.7%) with proximal spasticity. MAS was similar between the lower limbs in at least 6 of the 10 muscle groups of each individual. Spasticity was mostly mixed in the lower limbs, with more frequently mild severity. The individuals were partially symmetrical between the lower limbs. The most affected muscle groups were the plantiflexors, knee extensors and flexors and the hip adductors, consecutively, being predominantly symmetrical.



中文翻译:

HTLV-1相关脊髓病/热带痉挛性截瘫患者的痉挛分布和严重程度

在患有 HTLV-I 相关脊髓病/热带痉挛性截瘫 (HAM/TSP) 的个体中,痉挛是主要症状之一。该疾病的神经系统症状已明确定义,但尚未充分探索这些个体如何出现痉挛状态的细节。描述 HAM/TSP 个体的痉挛位置和严重程度。对 18 岁以上、诊断为 HAM/TSP 和下肢痉挛的个体进行的横断面研究。不包括孕妇、患有其他相关神经系统疾病的人以及使用抗痉挛药物的人。痉挛通过改良 Ashworth 量表 (MAS) 评估,适用于臀部的外展肌、内收肌、屈肌和伸肌、膝关节的屈肌和伸肌、背屈肌、跖屈肌、外翻肌和足部的内翻肌。包括三十名参与者。跖屈肌 (90%)、膝伸肌 (80%)、膝屈肌 (63.3%) 和内收肌 (50%) 最常受到痉挛的影响。23 人 (76.7%) 患有混合痉挛,5 人 (16.7%) 患有远端痉挛,2 人 (6.7%) 患有近端痉挛。每个人的 10 个肌肉群中至少有 6 个下肢的 MAS 相似。痉挛主要混合在下肢,更常见的是轻度严重。这些个体在下肢之间部分对称。受影响最大的肌肉群依次是跖屈肌、膝伸和屈肌以及髋内收肌,主要是对称的。7%) 个体患有混合痉挛,5 人 (16.7%) 患有远端痉挛,2 人 (6.7%) 患有近端痉挛。每个人的 10 个肌肉群中至少有 6 个下肢的 MAS 相似。痉挛主要混合在下肢,更常见的是轻度严重。这些个体在下肢之间部分对称。受影响最大的肌肉群依次是跖屈肌、膝伸和屈肌以及髋内收肌,主要是对称的。7%) 个体患有混合痉挛,5 人 (16.7%) 患有远端痉挛,2 人 (6.7%) 患有近端痉挛。每个人的 10 个肌肉群中至少有 6 个下肢的 MAS 相似。痉挛主要混合在下肢,更常见的是轻度严重。这些个体在下肢之间部分对称。受影响最大的肌肉群依次是跖屈肌、膝伸和屈肌以及髋内收肌,主要是对称的。

更新日期:2020-10-06
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