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In vivo cartilage regeneration in a multi-layered articular cartilage architecture mimicking scaffold.
Bone & Joint Research ( IF 4.6 ) Pub Date : 2020-09-23 , DOI: 10.1302/2046-3758.99.bjr-2019-0210.r2
Karthikeyan Rajagopal 1, 2 , Sowmya Ramesh 1, 2 , Noel Malcolm Walter 3 , Aditya Arora 4 , Dhirendra S Katti 4 , Vrisha Madhuri 1, 2
Affiliation  

Extracellular matrix (ECM) and its architecture have a vital role in articular cartilage (AC) structure and function. We hypothesized that a multi-layered chitosan-gelatin (CG) scaffold that resembles ECM, as well as native collagen architecture of AC, will achieve superior chondrogenesis and AC regeneration. We also compared its in vitro and in vivo outcomes with randomly aligned CG scaffold.

中文翻译:

模拟支架的多层关节软骨结构中的体内软骨再生。

细胞外基质 (ECM) 及其结构在关节软骨 (AC) 的结构和功能中起着至关重要的作用。我们假设类似于 ECM 的多层壳聚糖-明胶 (CG) 支架以及 AC 的天然胶原结构将实现卓越的软骨形成和 AC 再生。我们还将其体外和体内结果与随机排列的 CG 支架进行了比较。
更新日期:2020-10-07
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