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New Strategy against COVID-19: L-Serine Doped QDs for Fast Detection of COVID-19 and Blocking of S-Protein
ECS Journal of Solid State Science and Technology ( IF 2.2 ) Pub Date : 2020-10-05 , DOI: 10.1149/2162-8777/abbb9e
Samia Nasr 1 , Tarek Hidouri 2 , Ferjeni Zouidi 1
Affiliation  

To detect COVID-19, the reverse transcription-polymerase chain reaction (RT-PCR) is usually used but there is a number of faulty tests or an inexact diagnostic, especially in the primordial period of infection In this regard, the optical response of hybrid quantum dots (QDs): L-serine is presented for the first time as a new and rapid method of detection QDs were further conjugated with anti-infectious viruses' antibodies The detection of a target analyte is increased due to the fact that the final formed hybrid system is exposed to doses of L-serine optically active QDs acts as L-Serine's host This last will trap the virus and emerges less/high photoluminescence (PL) response depending on the L-serine, virus, and doping concentrations Such rapid optical treatment will inform us of the infection state faster and more efficiently than ELISA tests The fluorescence properties of the new hybrid system permit a control of coronavirus with a limit of detection LOD similar to 80 EID/50 mu l thanks to families of clusters induced by L-serine's molecules Families of L-serine clusters with inhomogeneous densities can block the S-protein in COVID-19 Moreover, the detection can be issued by trapping the virus with the same dopant

中文翻译:

针对 COVID-19 的新策略:L-丝氨酸掺杂量子点用于快速检测 COVID-19 和阻断 S-蛋白

为了检测 COVID-19,通常使用逆转录聚合酶链反应 (RT-PCR),但存在许多错误的测试或不准确的诊断,尤其是在感染的原始时期。量子点 (QD):L-丝氨酸作为一种新的快速检测方法首次出现 量子点进一步与抗感染病毒的抗体结合 由于最终形成的目标分析物增加了对目标分析物的检测混合系统暴露于一定剂量的 L-丝氨酸光学活性量子点作为 L-丝氨酸的宿主 这最后一个将捕获病毒并根据 L-丝氨酸、病毒、和掺杂浓度 这种快速的光学处理将比 ELISA 测试更快、更有效地告知我们感染状态 新型混合系统的荧光特性允许控制冠状病毒,其检测限 LOD 类似于 80 EID/50 微升,这要归功于L-丝氨酸分子诱导的簇家族 密度不均匀的 L-丝氨酸簇家族可以阻断 COVID-19 中的 S 蛋白 此外,可以通过用相同的掺杂剂捕获病毒来进行检测可以通过用相同的掺杂剂捕获病毒来进行检测可以通过用相同的掺杂剂捕获病毒来进行检测
更新日期:2020-10-05
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