Corilagin (CLG), a major component of several medicinal plants, can exhibit diverse pharmacological properties including those of anti-cancer, anti-inflammatory, and hepatoprotective qualities. However, there are no prior studies on its potential impact on the epithelial-to-mesenchymal transition (EMT) process. EMT can lead to dissemination of tumor cells into other organs and promote cancer progression. Hence, we aimed to investigate the effect of CLG on EMT and its mechanism(s) of action in tumor cells. We noted that CLG reduced the expression of various epithelial markers and up-regulated the expression of Occludin and E-cadherin in both basal and TGFβ-stimulated tumor cells. CLG treatment also abrogated cellular invasion and migration in colon and prostate carcinoma cells. In addition, CLG effectively attenuated the Wnt/β-catenin signaling cascade in TGFβ-stimulated cells. Overall, our study suggests that CLG may function as and effective modulator of EMT and metastasis in neoplastic cells.

中文翻译：

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Corilagin 通过调节 Wnt/β-Catenin 信号级联抑制上皮向间充质转化过程

Corilagin (CLG) 是几种药用植物的主要成分，具有多种药理特性，包括抗癌、抗炎和保肝特性。然而，之前没有关于其对上皮间质转化 (EMT) 过程的潜在影响的研究。EMT 可导致肿瘤细胞扩散到其他器官并促进癌症进展。因此，我们旨在研究 CLG 对 EMT 的影响及其在肿瘤细胞中的作用机制。我们注意到 CLG 降低了各种上皮标志物的表达，并上调了基底和 TGFβ 刺激的肿瘤细胞中 Occludin 和 E-钙粘蛋白的表达。CLG 治疗还消除了结肠癌和前列腺癌细胞中的细胞侵袭和迁移。此外，CLG 有效减弱了 TGFβ 刺激细胞中的 Wnt/β-catenin 信号级联反应。总体而言，我们的研究表明，CLG 可能作为 EMT 和肿瘤细胞转移的有效调节剂。